Neuronal pattern correlates with the severity of human immunodeficiency virus-associated dementia complex: Usefulness of spatial pattern analysis in clinicopathological studies

Enoch Asare, Graham Dunn, Jonathan Glass, Justin McArthur, Philip Luthert, Peter Lantos, Ian Everall

Research output: Contribution to journalArticlepeer-review

Abstract

The spatial distributional pattern of neurons, in the superior frontal gyrus of 32 subjects who died of acquired immune deficiency syndrome, was examined. The patients were classified as nondemented, mildly demented, and severely demented, and some were treated with the anti-retroviral drug zidovudine. Spatial statistical techniques were employed to investigate the degree of clustering in the individual cases and various groups. We found that the cluster pattern of large and small neurons differed significantly with increasing severity of dementia but was not influenced by the duration of zidovudine treatment. We conclude that this is a sensitive technique for clinicopathological correlations and that the differences may result from loss of specific neuronal populations, which could determine the degree of dementia.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalAmerican Journal of Pathology
Volume148
Issue number1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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