Neuronal GM1 gangliosidosis in a siamese cat with β-galactosidase deficiency

Henry J. Baker, J. Russell Lindsey, Guy M. McKhann, Donald F. Farrell

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM1 gangliosidosis of children.

Original languageEnglish (US)
Pages (from-to)838-839
Number of pages2
Issue number4011
StatePublished - 1971
Externally publishedYes

ASJC Scopus subject areas

  • General


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