Neuronal GM1 gangliosidosis in a siamese cat with β-galactosidase deficiency

Henry J. Baker, J. Russell Lindsey, Guy M. McKhann, Donald F. Farrell

Research output: Contribution to journalArticlepeer-review

Abstract

A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM1 gangliosidosis of children.

Original languageEnglish (US)
Pages (from-to)838-839
Number of pages2
JournalScience
Volume174
Issue number4011
DOIs
StatePublished - 1971

ASJC Scopus subject areas

  • General

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