Neuronal exosomal mirna-dependent translational regulation of astroglial glutamate transporter glt1

Lydie Morel; Melissa Regan; Haruki Higashimori; Seng Kah Ng; Christine Esau; Svetlana Vidensky; Jeffrey Rothstein; Yongjie Yang

doi:10.1074/jbc.M112.410944

Neuronal exosomal mirna-dependent translational regulation of astroglial glutamate transporter glt1

Lydie Morel, Melissa Regan, Haruki Higashimori, Seng Kah Ng, Christine Esau, Svetlana Vidensky, Jeffrey Rothstein, Yongjie Yang

School of Medicine

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal microRNA 124a can be transferred into astrocytes through neuronal exosomes and significantly increases GLT1 protein expression in an indirect manner. Conclusion: Neuronal exosomal miRNA 124a is able to regulate astroglial GLT1 expression. Significance: We characterize a novel pathway in neuron-to-astrocyte communication and identify a microRNA that modulates GLT1 protein expression.

Original language	English (US)
Pages (from-to)	7105-7116
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.410944
State	Published - Mar 8 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Neuronal exosomal mirna-dependent translational regulation of astroglial glutamate transporter glt1",

abstract = "Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal microRNA 124a can be transferred into astrocytes through neuronal exosomes and significantly increases GLT1 protein expression in an indirect manner. Conclusion: Neuronal exosomal miRNA 124a is able to regulate astroglial GLT1 expression. Significance: We characterize a novel pathway in neuron-to-astrocyte communication and identify a microRNA that modulates GLT1 protein expression.",

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AU - Morel, Lydie

AU - Regan, Melissa

AU - Higashimori, Haruki

AU - Ng, Seng Kah

AU - Esau, Christine

AU - Vidensky, Svetlana

AU - Rothstein, Jeffrey

AU - Yang, Yongjie

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal microRNA 124a can be transferred into astrocytes through neuronal exosomes and significantly increases GLT1 protein expression in an indirect manner. Conclusion: Neuronal exosomal miRNA 124a is able to regulate astroglial GLT1 expression. Significance: We characterize a novel pathway in neuron-to-astrocyte communication and identify a microRNA that modulates GLT1 protein expression.

AB - Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal microRNA 124a can be transferred into astrocytes through neuronal exosomes and significantly increases GLT1 protein expression in an indirect manner. Conclusion: Neuronal exosomal miRNA 124a is able to regulate astroglial GLT1 expression. Significance: We characterize a novel pathway in neuron-to-astrocyte communication and identify a microRNA that modulates GLT1 protein expression.

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Neuronal exosomal mirna-dependent translational regulation of astroglial glutamate transporter glt1

Abstract

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