Neuronal exosomal mirna-dependent translational regulation of astroglial glutamate transporter glt1

Lydie Morel, Melissa Regan, Haruki Higashimori, Seng Kah Ng, Christine Esau, Svetlana Vidensky, Jeffrey Rothstein, Yongjie Yang

Research output: Contribution to journalArticle

Abstract

Background: Pathways involved in neuron-dependent GLT1 regulation in astrocytes remain to be characterized. Results: Neuronal microRNA 124a can be transferred into astrocytes through neuronal exosomes and significantly increases GLT1 protein expression in an indirect manner. Conclusion: Neuronal exosomal miRNA 124a is able to regulate astroglial GLT1 expression. Significance: We characterize a novel pathway in neuron-to-astrocyte communication and identify a microRNA that modulates GLT1 protein expression.

Original languageEnglish (US)
Pages (from-to)7105-7116
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
StatePublished - Mar 8 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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