Neuronal evidence for individual eye control in the primate cMRF

David M. Waitzman, Marion R. Van Horn, Kathleen Cullen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Previous single unit recordings and electrical stimulation have suggested that separate regions of the MRF participate in the control of vergence and conjugate eye movements. Neurons in the supraoculomotor area (SOA) have been found to encode symmetric vergence [Zhang, Y. et al. (1992). J. Neurophysiol., 67: 944-960] while neurons in the central MRF, the cMRF, located ventral to the SOA and lateral to the oculomotor nucleus are associated with conjugate eye movements [Waitzman, D.M. et al. (1996). J. Neurophysiol., 75(4): 1546-1572]. However, it remains unknown if cMRF neurons are strictly associated with conjugate movements since eye movements were recorded with a single eye coil in monkeys viewing visual stimuli at a distance of at least 50 cm. In the current study we addressed whether neurons in the cMRF might also encode vergence-related information. Interestingly, electrical stimulation elicited disconjugate saccades (contralateral eye moved more than the ipsilateral eye) from locations previously thought to elicit only conjugate saccades. Single unit recordings in this same area made in two rhesus monkeys trained to follow visual stimuli moved rapidly in depth along the axis of sight of an individual eye demonstrate that cMRF neurons do not simply encode conjugate information during disconjugate saccades; in fact our findings provide evidence that cMRF neurons are most closely associated with the movement of an individual eye. These results support the hypothesis that the midbrain shapes the activity of the pre-motor saccadic neurons by encoding integrated conjugate and vergence commands.

Original languageEnglish (US)
Title of host publicationUsing Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
Pages143-150
Number of pages8
Volume171
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameProgress in Brain Research
Volume171
ISSN (Print)00796123

Fingerprint

Primates
Eye Movements
Neurons
Saccades
Electric Stimulation
Motor Neurons
Mesencephalon
Macaca mulatta
Haplorhini

Keywords

  • disconjugate eye movement
  • disparity
  • mesencephalic reticular formation (MRF)
  • oculomotor system
  • saccade
  • saccade-vergence interaction
  • superior colliculus (SC)
  • supraoculomotor area (SOA)
  • vergence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Waitzman, D. M., Van Horn, M. R., & Cullen, K. (2008). Neuronal evidence for individual eye control in the primate cMRF. In Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever (Vol. 171, pp. 143-150). (Progress in Brain Research; Vol. 171). https://doi.org/10.1016/S0079-6123(08)00619-5

Neuronal evidence for individual eye control in the primate cMRF. / Waitzman, David M.; Van Horn, Marion R.; Cullen, Kathleen.

Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Vol. 171 2008. p. 143-150 (Progress in Brain Research; Vol. 171).

Research output: Chapter in Book/Report/Conference proceedingChapter

Waitzman, DM, Van Horn, MR & Cullen, K 2008, Neuronal evidence for individual eye control in the primate cMRF. in Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. vol. 171, Progress in Brain Research, vol. 171, pp. 143-150. https://doi.org/10.1016/S0079-6123(08)00619-5
Waitzman DM, Van Horn MR, Cullen K. Neuronal evidence for individual eye control in the primate cMRF. In Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Vol. 171. 2008. p. 143-150. (Progress in Brain Research). https://doi.org/10.1016/S0079-6123(08)00619-5
Waitzman, David M. ; Van Horn, Marion R. ; Cullen, Kathleen. / Neuronal evidence for individual eye control in the primate cMRF. Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Vol. 171 2008. pp. 143-150 (Progress in Brain Research).
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