Neuronal disorders: Studies of animal models and human diseases

D. L. Price, S. S. Sisodia, E. H. Koo, N. A. Muma, C. A. Kitt, L. C. Walker, L. J. Martin, J. C. Troncoso, J. W. Griffin, P. N. Hoffman, L. C. Cork

Research output: Contribution to journalArticle

Abstract

The peripheral nervous system and the central nervous system (CNS) are comprised of assemblies of neurons that communicate via electrical and chemical signals. Different disease processes selectively affect specific populations of neurons and/or specific cell functions (i.e., 'selective vulnerability' of neurons is a principal determinant of phenotypes of disease). New cellular and molecular biological approaches have begun to clarify some of the mechanisms of selective cell injury in human disease and their animal models. Following a brief review of the normal biology of nerve cells, we use illustrations drawn from studies of experimental and human diseases to discuss the mechanisms of structural/chemical abnormalities that occur in a variety of neuronal disorders.

Original languageEnglish (US)
Pages (from-to)128-137
Number of pages10
JournalToxicologic pathology
Volume18
Issue number1 II
StatePublished - Jul 4 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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  • Cite this

    Price, D. L., Sisodia, S. S., Koo, E. H., Muma, N. A., Kitt, C. A., Walker, L. C., Martin, L. J., Troncoso, J. C., Griffin, J. W., Hoffman, P. N., & Cork, L. C. (1990). Neuronal disorders: Studies of animal models and human diseases. Toxicologic pathology, 18(1 II), 128-137.