Neuronal Death and Neuroprotection after Stroke and Brain Trauma

Peter Vosler, S. Chen, J. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acute neuronal injury from stroke and traumatic brain injury (TBI) starts a sequela of both extra- and intracellular events that ultimately leads to the demise of the affected brain tissue comprising neurons, glia, and endothelial cells lining the vasculature - the neurovascular unit. This article discusses the initial insults that separate stroke from TBI, and the common factors that lead to brain cell death and neurological dysfunction. Finally, various strategies currently being tested to provide neuroprotection are discussed in relation to acute neuronal injury.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages437-440
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Astrocytosis
  • Autophagy
  • Caspases
  • Cell-based therapy
  • Cerebral ischemia
  • Neuroinflammation
  • Neuroprotection
  • Neurovascular unit
  • PARP-1
  • Preconditioning
  • Programmed cell death
  • Reactive oxygen species
  • Stroke
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Vosler, P., Chen, S., & Chen, J. (2014). Neuronal Death and Neuroprotection after Stroke and Brain Trauma. In Encyclopedia of the Neurological Sciences (pp. 437-440). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00580-7