Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration

Ashley M. Blouin, Anna L. Stern, Sungho Han, Florence R. Theberge, Chuansong Wang, Matthew J. During, Jay M. Baraban, Irving M. Reti

Research output: Contribution to journalArticlepeer-review

Abstract

The medial prefrontal cortex (mPFC) plays a key role in extinction learning. Previously, we found that expression of a neuronal activity-regulated pentraxin (Narp) dominant-negative construct in the mPFC of mice blocked extinction of morphine-conditioned place preference. To further investigate the role of mPFC Narp in the extinction of drug seeking, we tested whether mPFC Narp is necessary for the extinction of heroin self-administration in rats. Specifically, we injected an adeno-associated viral vector expressing a dominant-negative form of Narp (NarpN) into the infralimbic region of the mPFC of rats and compared lever presses during extinction to those of rats injected with a control virus. In contrast to our previous study, we found that injection of NarpN did not affect extinction of heroin self-administration. Our findings suggest that mPFC Narp is necessary for extinction of opiate seeking in the Pavlovian-conditioned place preference paradigm but not in the operant paradigm of drug self-administration.

Original languageEnglish (US)
Pages (from-to)332-336
Number of pages5
JournalBehavioural Pharmacology
Volume24
Issue number4
DOIs
StatePublished - Aug 2013

Keywords

  • Addiction
  • Extinction
  • Heroin
  • Neuronal activity-regulated pentraxin
  • Prefrontal cortex
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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