Neuronal activity and the expression of clathrin-assembly protein AP180

Fangbai Wu; Mark P. Mattson; Pamela J. Yao

doi:10.1016/j.bbrc.2010.10.018

Neuronal activity and the expression of clathrin-assembly protein AP180

Fangbai Wu, Mark P. Mattson, Pamela J. Yao

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The clathrin-assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin-assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	402
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2010.10.018
State	Published - Nov 12 2010
Externally published	Yes

Keywords

AP180
CALM
Epsin1
HIP1
Hippocampal neuron

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Molecular Biology

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10.1016/j.bbrc.2010.10.018

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abstract = "The clathrin-assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin-assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity.",

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AU - Mattson, Mark P.

AU - Yao, Pamela J.

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AB - The clathrin-assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin-assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity.

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KW - CALM

KW - Epsin1

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KW - Hippocampal neuron

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Neuronal activity and the expression of clathrin-assembly protein AP180

Abstract

Keywords

ASJC Scopus subject areas

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