Neuronal activity and the expression of clathrin-assembly protein AP180

Fangbai Wu, Mark P. Mattson, Pamela J. Yao

Research output: Contribution to journalArticlepeer-review

Abstract

The clathrin-assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin-assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume402
Issue number2
DOIs
StatePublished - Nov 12 2010
Externally publishedYes

Keywords

  • AP180
  • CALM
  • Epsin1
  • HIP1
  • Hippocampal neuron

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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