Neuron simulations with SABER

N. T. Carnevale, T. B. Woolf, G. M. Shepherd

Research output: Contribution to journalArticlepeer-review

Abstract

Computational models can provide critical tests of hypotheses of neuronal function. These models are essential for dealing with the complications of time- and voltage-dependent (active) ionic conductances. Commercial circuit analysis programs have been useful tools for this work. We report our experience modelling biophysically realistic membrane properties with SABER (Analogy, Inc.), a new general purpose simulator. SABER allows construction of models with arbitrary membrane properties. This is a major advantage over similar programs (e.g. SPICE), which are limited to a predefined library of electronic components. The empirically determined equations that describe rate constants, ionic conductances, currents, and concentration shifts can be translated directly into model elements ('templates') written in C-like code. We describe the development of SABER models that simulate a synapse and an action potential.

Original languageEnglish (US)
Pages (from-to)135-148
Number of pages14
JournalJournal of Neuroscience Methods
Volume33
Issue number2-3
DOIs
StatePublished - Aug 1990
Externally publishedYes

Keywords

  • Action potential
  • Electrophysiology
  • Electrotonus
  • Neuronal modeling
  • Simulation

ASJC Scopus subject areas

  • Neuroscience(all)

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