Abstract
Computational models can provide critical tests of hypotheses of neuronal function. These models are essential for dealing with the complications of time- and voltage-dependent (active) ionic conductances. Commercial circuit analysis programs have been useful tools for this work. We report our experience modelling biophysically realistic membrane properties with SABER (Analogy, Inc.), a new general purpose simulator. SABER allows construction of models with arbitrary membrane properties. This is a major advantage over similar programs (e.g. SPICE), which are limited to a predefined library of electronic components. The empirically determined equations that describe rate constants, ionic conductances, currents, and concentration shifts can be translated directly into model elements ('templates') written in C-like code. We describe the development of SABER models that simulate a synapse and an action potential.
Original language | English (US) |
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Pages (from-to) | 135-148 |
Number of pages | 14 |
Journal | Journal of Neuroscience Methods |
Volume | 33 |
Issue number | 2-3 |
DOIs | |
State | Published - Aug 1990 |
Externally published | Yes |
Keywords
- Action potential
- Electrophysiology
- Electrotonus
- Neuronal modeling
- Simulation
ASJC Scopus subject areas
- General Neuroscience