TY - JOUR
T1 - Neuron-glia interactions clarify genetic-environmental links in mental illness
AU - Sawa, Akira
AU - Pletnikov, Mikhail V.
AU - Kamiya, Atsushi
PY - 2004/6
Y1 - 2004/6
N2 - How genes and environment interface to generate major psychiatric disorders such as schizophrenia has been puzzling, as are the relative roles of neurons and glia in such disturbances. Tomonaga and colleagues have recently reported striking neurobehavioral abnormalities in mice expressing Borna disease virus phosphoprotein (BDV-P) selectively in glial cells. The study provides a novel approach of linking environmental and genetic factors to behavior by producing genetically engineered mice. The key role for glial BDV-P implicates neuron-glia interactions in the pathogenesis of psychiatric conditions.
AB - How genes and environment interface to generate major psychiatric disorders such as schizophrenia has been puzzling, as are the relative roles of neurons and glia in such disturbances. Tomonaga and colleagues have recently reported striking neurobehavioral abnormalities in mice expressing Borna disease virus phosphoprotein (BDV-P) selectively in glial cells. The study provides a novel approach of linking environmental and genetic factors to behavior by producing genetically engineered mice. The key role for glial BDV-P implicates neuron-glia interactions in the pathogenesis of psychiatric conditions.
UR - http://www.scopus.com/inward/record.url?scp=2542507335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542507335&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2004.03.012
DO - 10.1016/j.tins.2004.03.012
M3 - Short survey
C2 - 15165731
AN - SCOPUS:2542507335
VL - 27
SP - 294
EP - 297
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 6
ER -