Neuromyelitis optica and multiple sclerosis

Seeing differences through optical coherence tomography

J. L. Bennett, J. de Seze, M. Lana-Peixoto, J. Palace, A. Waldman, B. Banwell, S. Schippling, S. Tenembaum, B. Greenberg, Michael Levy, K. Fujihara, K. H. Chan, H. J. Kim, N. Asgari, D. K. Sato, A. Saiz, P. Villoslada, H. Zimmermann, J. Wuerfel, A. Green & 1 others F. Paul

Research output: Contribution to journalReview article

Abstract

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

Original languageEnglish (US)
Pages (from-to)678-688
Number of pages11
JournalMultiple Sclerosis Journal
Volume21
Issue number6
DOIs
StatePublished - 2015

Fingerprint

Neuromyelitis Optica
Optical Coherence Tomography
Multiple Sclerosis
Optic Neuritis
Nerve Fibers
Autoimmune Diseases of the Nervous System
Aquaporin 4
Aquaporins
Macular Edema
Optic Nerve
Ganglia
Autoantibodies
Spinal Cord
Central Nervous System
Serum

Keywords

  • ganglion cell layer
  • multiple sclerosis
  • Neuromyelitis optica
  • optic neuritis
  • optical coherence tomography
  • retinal nerve fiber layer

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bennett, J. L., de Seze, J., Lana-Peixoto, M., Palace, J., Waldman, A., Banwell, B., ... Paul, F. (2015). Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis Journal, 21(6), 678-688. https://doi.org/10.1177/1352458514567216

Neuromyelitis optica and multiple sclerosis : Seeing differences through optical coherence tomography. / Bennett, J. L.; de Seze, J.; Lana-Peixoto, M.; Palace, J.; Waldman, A.; Banwell, B.; Schippling, S.; Tenembaum, S.; Greenberg, B.; Levy, Michael; Fujihara, K.; Chan, K. H.; Kim, H. J.; Asgari, N.; Sato, D. K.; Saiz, A.; Villoslada, P.; Zimmermann, H.; Wuerfel, J.; Green, A.; Paul, F.

In: Multiple Sclerosis Journal, Vol. 21, No. 6, 2015, p. 678-688.

Research output: Contribution to journalReview article

Bennett, JL, de Seze, J, Lana-Peixoto, M, Palace, J, Waldman, A, Banwell, B, Schippling, S, Tenembaum, S, Greenberg, B, Levy, M, Fujihara, K, Chan, KH, Kim, HJ, Asgari, N, Sato, DK, Saiz, A, Villoslada, P, Zimmermann, H, Wuerfel, J, Green, A & Paul, F 2015, 'Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography', Multiple Sclerosis Journal, vol. 21, no. 6, pp. 678-688. https://doi.org/10.1177/1352458514567216
Bennett, J. L. ; de Seze, J. ; Lana-Peixoto, M. ; Palace, J. ; Waldman, A. ; Banwell, B. ; Schippling, S. ; Tenembaum, S. ; Greenberg, B. ; Levy, Michael ; Fujihara, K. ; Chan, K. H. ; Kim, H. J. ; Asgari, N. ; Sato, D. K. ; Saiz, A. ; Villoslada, P. ; Zimmermann, H. ; Wuerfel, J. ; Green, A. ; Paul, F. / Neuromyelitis optica and multiple sclerosis : Seeing differences through optical coherence tomography. In: Multiple Sclerosis Journal. 2015 ; Vol. 21, No. 6. pp. 678-688.
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