Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

J. L. Bennett; J. de Seze; M. Lana-Peixoto; J. Palace; A. Waldman; B. Banwell; S. Schippling; S. Tenembaum; B. Greenberg; M. Levy; K. Fujihara; K. H. Chan; H. J. Kim; N. Asgari; D. K. Sato; A. Saiz; P. Villoslada; H. Zimmermann; J. Wuerfel; A. Green; F. Paul

doi:10.1177/1352458514567216

Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

J. L. Bennett, J. de Seze, M. Lana-Peixoto, J. Palace, A. Waldman, B. Banwell, S. Schippling, S. Tenembaum, B. Greenberg, M. Levy, K. Fujihara, K. H. Chan, H. J. Kim, N. Asgari, D. K. Sato, A. Saiz, P. Villoslada, H. Zimmermann, J. Wuerfel, A. GreenF. Paul

School of Medicine

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

Original language	English (US)
Pages (from-to)	678-688
Number of pages	11
Journal	Multiple Sclerosis Journal
Volume	21
Issue number	6
DOIs	https://doi.org/10.1177/1352458514567216
State	Published - May 2015

Keywords

Neuromyelitis optica
ganglion cell layer
multiple sclerosis
optic neuritis
optical coherence tomography
retinal nerve fiber layer

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Bennett, J. L., de Seze, J., Lana-Peixoto, M., Palace, J., Waldman, A., Banwell, B., Schippling, S., Tenembaum, S., Greenberg, B., Levy, M., Fujihara, K., Chan, K. H., Kim, H. J., Asgari, N., Sato, D. K., Saiz, A., Villoslada, P., Zimmermann, H., Wuerfel, J., ... Paul, F. (2015). Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis Journal, 21(6), 678-688. https://doi.org/10.1177/1352458514567216

Bennett, JL, de Seze, J, Lana-Peixoto, M, Palace, J, Waldman, A, Banwell, B, Schippling, S, Tenembaum, S, Greenberg, B, Levy, M, Fujihara, K, Chan, KH, Kim, HJ, Asgari, N, Sato, DK, Saiz, A, Villoslada, P, Zimmermann, H, Wuerfel, J, Green, A & Paul, F 2015, 'Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography', Multiple Sclerosis Journal, vol. 21, no. 6, pp. 678-688. https://doi.org/10.1177/1352458514567216

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title = "Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography",

abstract = "Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients{\textquoteright} RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.",

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author = "Bennett, {J. L.} and {de Seze}, J. and M. Lana-Peixoto and J. Palace and A. Waldman and B. Banwell and S. Schippling and S. Tenembaum and B. Greenberg and M. Levy and K. Fujihara and Chan, {K. H.} and Kim, {H. J.} and N. Asgari and Sato, {D. K.} and A. Saiz and P. Villoslada and H. Zimmermann and J. Wuerfel and A. Green and F. Paul",

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year = "2015",

month = may,

doi = "10.1177/1352458514567216",

language = "English (US)",

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T2 - Seeing differences through optical coherence tomography

AU - Bennett, J. L.

AU - de Seze, J.

AU - Lana-Peixoto, M.

AU - Palace, J.

AU - Waldman, A.

AU - Banwell, B.

AU - Schippling, S.

AU - Tenembaum, S.

AU - Greenberg, B.

AU - Levy, M.

AU - Fujihara, K.

AU - Chan, K. H.

AU - Kim, H. J.

AU - Asgari, N.

AU - Sato, D. K.

AU - Saiz, A.

AU - Villoslada, P.

AU - Zimmermann, H.

AU - Wuerfel, J.

AU - Green, A.

AU - Paul, F.

N1 - Funding Information: This work was supported by the German Ministry for Education and Research (Competence Network Multiple Sclerosis) (to FP).

PY - 2015/5

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N2 - Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

AB - Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

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Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

Abstract

Keywords

ASJC Scopus subject areas

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