Neuromyelitis optica: An antibody-mediated disorder of the central nervous system

Jiwon Oh, Michael Levy

Research output: Contribution to journalArticle

Abstract

Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord leading to blindness and paralysis. The hallmarks of NMO include bilateral optic neuritis and longitudinally extensive transverse myelitis. Woman and African Americans are overrepresented in the US patient population. NMO is associated with the NMO-IgG biomarker, which targets the aquaporin-4 water channel on astrocytes. The humoral pathology of NMO lesions include IgG and IgM deposits and infiltration by granulocytes suggesting that the NMO-IgG may be involved in the pathogenesis of disease. This review of the recent NMO literature covers the clinical features, epidemiology, radiology and pathology of disease and includes discussion of the important basic science research work in the field.

Original languageEnglish (US)
Article number460825
JournalNeurology Research International
Volume2012
DOIs
StatePublished - 2012

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Neuromyelitis Optica
Central Nervous System Diseases
Antibodies
Immunoglobulin G
Transverse Myelitis
Aquaporin 4
Pathology
Optic Neuritis
Aquaporins
Blindness
Optic Nerve
Granulocytes
Radiology
Astrocytes
Paralysis
African Americans
Immunoglobulin M
Spinal Cord
Epidemiology
Biomarkers

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Neuromyelitis optica : An antibody-mediated disorder of the central nervous system. / Oh, Jiwon; Levy, Michael.

In: Neurology Research International, Vol. 2012, 460825, 2012.

Research output: Contribution to journalArticle

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