Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Douglas M. Fambrough; Daniel B. Drachman; S. Satyamurti

doi:10.1126/science.182.4109.293

Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Douglas M. Fambrough, Daniel B. Drachman, S. Satyamurti

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of ¹²⁵I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

Original language	English (US)
Pages (from-to)	293-295
Number of pages	3
Journal	Science
Volume	182
Issue number	4109
DOIs	https://doi.org/10.1126/science.182.4109.293
State	Published - Jan 1 1973

ASJC Scopus subject areas

General

Access to Document

10.1126/science.182.4109.293

Cite this

@article{9f84d3c6db02452d8ebe6cab0884c600,

title = "Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors",

abstract = "The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.",

author = "Fambrough, {Douglas M.} and Drachman, {Daniel B.} and S. Satyamurti",

year = "1973",

month = jan,

day = "1",

doi = "10.1126/science.182.4109.293",

language = "English (US)",

volume = "182",

pages = "293--295",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4109",

}

TY - JOUR

T1 - Neuromuscular junction in myasthenia gravis

T2 - Decreased acetylcholine receptors

AU - Fambrough, Douglas M.

AU - Drachman, Daniel B.

AU - Satyamurti, S.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

AB - The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

UR - http://www.scopus.com/inward/record.url?scp=0015885733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015885733&partnerID=8YFLogxK

U2 - 10.1126/science.182.4109.293

DO - 10.1126/science.182.4109.293

M3 - Article

C2 - 4742736

AN - SCOPUS:0015885733

VL - 182

SP - 293

EP - 295

JO - Science

JF - Science

SN - 0036-8075

IS - 4109

ER -

Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this