Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Douglas M. Fambrough; Daniel B. Drachman; S. Satyamurti

doi:10.1126/science.182.4109.293

Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Douglas M. Fambrough, Daniel B. Drachman, S. Satyamurti

School of Medicine

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468 Scopus citations

Abstract

The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of ¹²⁵I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

Original language	English (US)
Pages (from-to)	293-295
Number of pages	3
Journal	Science
Volume	182
Issue number	4109
DOIs	https://doi.org/10.1126/science.182.4109.293
State	Published - 1973

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abstract = "The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.",

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AB - The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

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Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Abstract

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