Neuromuscular junction in myasthenia gravis: Decreased acetylcholine receptors

Douglas M. Fambrough, Daniel B. Drachman, S. Satyamurti

Research output: Contribution to journalArticle

Abstract

The number of acetylcholine receptors was determined in the neuro-muscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalScience
Volume182
Issue number4109
DOIs
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • General

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