Neuromodulation of Courtship Drive through Tyramine-Responsive Neurons in the Drosophila Brain

Jia Huang, Weiwei Liu, Yi xiang Qi, Junjie Luo, Craig Montell

Research output: Contribution to journalArticle

Abstract

Neuromodulators influence the activities of collections of neurons and have profound impacts on animal behavior. Male courtship drive is complex and subject to neuromodulatory control. Using the fruit fly Drosophila melanogaster, we identified neurons in the brain (inferior posterior slope; IPS) that impact courtship drive and were controlled by tyramine—a biogenic amine related to dopamine, whose roles in most animals are enigmatic. We knocked out a tyramine-specific receptor, TyrR, which was expressed in IPS neurons. Loss of TyrR led to a striking elevation in courtship activity between males. This effect occurred only in the absence of females, as TyrRGal4 mutant males exhibited a wild-type preference for females. Artificial hyperactivation of IPS neurons caused a large increase in male-male courtship, whereas suppression of IPS activity decreased male-female courtship. We conclude that TyrR is a receptor for tyramine, and suggest that it serves to curb high levels of courtship activity through functioning as an inhibitory neuromodulator.

Original languageEnglish (US)
Pages (from-to)2246-2256
Number of pages11
JournalCurrent Biology
Volume26
Issue number17
DOIs
StatePublished - Sep 12 2016
Externally publishedYes

Fingerprint

Courtship
Tyramine
tyramine
courtship
Drosophila
Neurons
Brain
neurons
brain
Neurotransmitter Agents
Animals
neurotransmitters
Curbs
Biogenic Amines
Fruits
Dopamine
Animal Behavior
receptors
biogenic amines
fruit flies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Neuromodulation of Courtship Drive through Tyramine-Responsive Neurons in the Drosophila Brain. / Huang, Jia; Liu, Weiwei; Qi, Yi xiang; Luo, Junjie; Montell, Craig.

In: Current Biology, Vol. 26, No. 17, 12.09.2016, p. 2246-2256.

Research output: Contribution to journalArticle

Huang, Jia ; Liu, Weiwei ; Qi, Yi xiang ; Luo, Junjie ; Montell, Craig. / Neuromodulation of Courtship Drive through Tyramine-Responsive Neurons in the Drosophila Brain. In: Current Biology. 2016 ; Vol. 26, No. 17. pp. 2246-2256.
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