Neuromodulation for Dystonia. Target and Patient Selection.

Kelly A. Mills, Philip A. Starr, Jill L. Ostrem

Research output: Contribution to journalReview article

Abstract

Treatment of dystonia refractory to oral medications or botulinum toxin injections includes the use of deep brain stimulation (DBS). Expectations should be established based on patient-related factors, including type of dystonia, genetic cause, target symptoms, age at the time of surgery, disease duration, or the presence of fixed skeletal deformities. Premorbid conditions such as psychiatric illness and cognitive impairment should be considered. Target selection is an emerging issue in DBS for dystonia. Although efficacy has been established for targeting the globus pallidus internus for dystonia, other brain targets such as the subthalamic nucleus, thalamus, or cortex may be promising alternatives.

Original languageEnglish (US)
Pages (from-to)59-75
Number of pages17
JournalNeurosurgery clinics of North America
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Brain target
  • Deep brain stimulation
  • Globus pallidus
  • Outcomes
  • Predictive factors
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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