Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla

Georg Oeltzschner, S. Andrea Wijtenburg, Mark Mikkelsen, Richard Anthony Edward Edden, Peter B Barker, Jin Hui Joo, Jeannie-Marie S Leoutsakos, Laura M. Rowland, Clifford I. Workman, Gwenn Smith

Research output: Contribution to journalArticle

Abstract

The levels of several brain metabolites were investigated in the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) in 13 healthy controls (HC) and 13 patients with mild cognitive impairment (MCI) using single-voxel magnetic resonance spectroscopy at 7T. Levels of γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartylglutamate (NAAG), N-acetylaspartate (NAA), and myo-inositol (mI) were quantified relative to total creatine (tCr). The effect of diagnosis on metabolite levels, and relationships between metabolite levels and memory and executive function, correcting for age, were investigated. MCI patients showed significantly decreased GABA/tCr (ACC, PCC), Glu/tCr (PCC), and NAA/tCr (PCC), and significantly increased mI/tCr (ACC). In the combined group, worse episodic verbal memory performance was correlated with lower Glu/tCr (PCC), lower NAA/tCr (PCC), and higher mI/tCr (ACC, PCC). Worse verbal fluency performance was correlated with lower GSH/tCr (PCC). In summary, MCI is associated with decreased GABA and Glu, most consistently in the PCC. Further studies in larger patient samples should be undertaken to determine the utility of 7T magnetic resonance spectroscopy in detecting MCI-related neurochemical changes.

LanguageEnglish (US)
Pages211-218
Number of pages8
JournalNeurobiology of Aging
Volume73
DOIs
StatePublished - Jan 1 2019

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Gyrus Cinguli
Creatine
Magnetic Resonance Spectroscopy
gamma-Aminobutyric Acid
Glutamic Acid
Inositol
Cognitive Dysfunction
Episodic Memory
Executive Function
Glutathione

Keywords

  • 7T
  • Anterior cingulate cortex
  • GABA
  • Glutamate
  • Magnetic resonance spectroscopy
  • Mild cognitive impairment
  • Posterior cingulate cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Neurometabolites and associations with cognitive deficits in mild cognitive impairment : a magnetic resonance spectroscopy study at 7 Tesla. / Oeltzschner, Georg; Wijtenburg, S. Andrea; Mikkelsen, Mark; Edden, Richard Anthony Edward; Barker, Peter B; Joo, Jin Hui; Leoutsakos, Jeannie-Marie S; Rowland, Laura M.; Workman, Clifford I.; Smith, Gwenn.

In: Neurobiology of Aging, Vol. 73, 01.01.2019, p. 211-218.

Research output: Contribution to journalArticle

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