Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence

Naohiro Okada, Noriaki Yahata, Daisuke Koshiyama, Kentaro Morita, Kingo Sawada, Sho Kanata, Shinya Fujikawa, Noriko Sugimoto, Rie Toriyama, Mio Masaoka, Shinsuke Koike, Tsuyoshi Araki, Yukiko Kano, Kaori Endo, Syudo Yamasaki, Shuntaro Ando, Atsushi Nishida, Mariko Hiraiwa-Hasegawa, Richard A.E. Edden, Peter B. BarkerAkira Sawa, Kiyoto Kasai

Research output: Contribution to journalArticlepeer-review

Abstract

Human prosocial behavior (PB) emerges in childhood and matures during adolescence. Previous task-related functional magnetic resonance imaging (fMRI) studies have reported involvement of the medial prefrontal cortex including the anterior cingulate cortex (ACC) in social cognition in adolescence. However, neurometabolic and functional connectivity (FC) basis of PB in early adolescence remains unclear. Here, we measured GABA levels in the ACC and FC in a subsample (aged 10.5–13.4 years) of a large-scale population-based cohort with MR spectroscopy (MEGA-PRESS) and resting-state fMRI. PB was negatively correlated with GABA levels in the ACC (N = 221), and positively correlated with right ACC-seeded FC with the right precentral gyrus and the bilateral middle and posterior cingulate gyrus (N = 187). Furthermore, GABA concentrations and this FC were negatively correlated, and the FC mediated the association between GABA levels and PB (N = 171). Our results from a minimally biased, large-scale sample provide new insights into the neurometabolic and neurofunctional correlates of prosocial development during early adolescence.

Original languageEnglish (US)
Article number732
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • General

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