Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors: A Report from the CoreValve Trials

Neal S. Kleiman, Brijeshwar J. Maini, Michael J. Reardon, John Conte, Stanley Katz, Vivek Rajagopal, James Kauten, Alan Hartman, Raymond McKay, Robert Hagberg, Jian Huang, Jeffrey Popma

Research output: Contribution to journalArticle

Abstract

Results-Patients enrolled in the CoreValve US Extreme Risk and High Risk Pivotal Trials or Continued Access Study treated with the self-expanding CoreValve bioprosthesis were included in this analysis. The 1-year stroke rate after TAVR was 8.4%. Analysis of the stroke hazard rate identified an early phase (0-10 days; 4.1% of strokes) and a late phase (11-365 days; 4.3% of strokes). Baseline predictors of early stroke included National Institutes of Health stroke scale score 0, prior stroke, prior transient ischemic attack, peripheral vascular disease, absence of prior coronary artery bypass surgery, angina, low body mass index (21kg/m), and falls within the past 6 months. Significant procedural predictors were total time in the catheterization laboratory or operating room, delivery catheter in the body time, rapid pacing used during valvuloplasty, and repositioning of the prosthesis. Predictors of stroke between 11 and 365 days were small body surface area, severe aortic calcification, and falls within the past 6 months. There were no significant imaging predictors of early or late stroke. Conclusions-Predictors of early stroke after TAVR included clinical and procedural factors; predictors of later stroke were limited to patient but not anatomic characteristics. These findings indicate that further refinement of imaging to identify anatomic factors predisposing to embolization may help improve stroke prediction in patients undergoing TAVR.

Original languageEnglish (US)
Article numbere003551
JournalCirculation: Cardiovascular Interventions
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • Aortic valve stenosis
  • CoreValve
  • stroke
  • transcatheter aortic valve implantation
  • transient ischemic attack

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Kleiman, N. S., Maini, B. J., Reardon, M. J., Conte, J., Katz, S., Rajagopal, V., Kauten, J., Hartman, A., McKay, R., Hagberg, R., Huang, J., & Popma, J. (2016). Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors: A Report from the CoreValve Trials. Circulation: Cardiovascular Interventions, 9(9), [e003551]. https://doi.org/10.1161/CIRCINTERVENTIONS.115.003551