Neurological complications of HIV infection

Justin C. McArthur, Bruce J. Brew, Avi Nath

Research output: Contribution to journalReview articlepeer-review

Abstract

Cognitive disorders, vacuolar myelopathy, and sensory neuropathies associated with HIV are the most common disorders in patients with HIV AIDS, and are the focus of this review. These disorders are treatable and of those associated with HIV AIDS the pathogenic mechanisms are the most understood. Although triggered by productive HIV macrophage infections, aberrant immune activation plays a major role in inducing the CNS disorders. Novel therapies aimed at these inflammatory mechanisms can be effective. The sensory neuropathies associated with HIV infection are a major cause of morbidity; incidence may be increased by the toxic effects of specific antiretroviral drugs within the peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)543-555
Number of pages13
JournalLancet Neurology
Volume4
Issue number9
DOIs
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Clinical Neurology

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