Neurological Complications of Ebola Virus Infection

Bridgette Jeanne Billioux, Bryan Smith, Avindra Nath

Research output: Contribution to journalArticle

Abstract

Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalNeurotherapeutics
DOIs
StateAccepted/In press - Jul 13 2016
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Disease Outbreaks
Neurologic Manifestations
Headache
Survivors
Seizures
Central Nervous System
Meningoencephalitis
Western Africa
Cranial Nerves
Memory Disorders
Tremor
Acute Disease
Coma
Nervous System
Vomiting
Diarrhea
Fever
Learning
Recurrence

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Cite this

Neurological Complications of Ebola Virus Infection. / Billioux, Bridgette Jeanne; Smith, Bryan; Nath, Avindra.

In: Neurotherapeutics, 13.07.2016, p. 1-10.

Research output: Contribution to journalArticle

Billioux, Bridgette Jeanne ; Smith, Bryan ; Nath, Avindra. / Neurological Complications of Ebola Virus Infection. In: Neurotherapeutics. 2016 ; pp. 1-10.
@article{a820d3f5cc9448fdbb595919ac320bb4,
title = "Neurological Complications of Ebola Virus Infection",
abstract = "Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90{\%} depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.",
author = "Billioux, {Bridgette Jeanne} and Bryan Smith and Avindra Nath",
year = "2016",
month = "7",
day = "13",
doi = "10.1007/s13311-016-0457-z",
language = "English (US)",
pages = "1--10",
journal = "Neurotherapeutics",
issn = "1933-7213",
publisher = "Springer New York",

}

TY - JOUR

T1 - Neurological Complications of Ebola Virus Infection

AU - Billioux, Bridgette Jeanne

AU - Smith, Bryan

AU - Nath, Avindra

PY - 2016/7/13

Y1 - 2016/7/13

N2 - Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.

AB - Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.

UR - http://www.scopus.com/inward/record.url?scp=84978114927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978114927&partnerID=8YFLogxK

U2 - 10.1007/s13311-016-0457-z

DO - 10.1007/s13311-016-0457-z

M3 - Article

C2 - 27412684

AN - SCOPUS:84978114927

SP - 1

EP - 10

JO - Neurotherapeutics

JF - Neurotherapeutics

SN - 1933-7213

ER -