Neurologic outcomes in retinopathynegative cerebral malaria survivors

Douglas G. Postels, Terrie E. Taylor, Malcolm Molyneux, Kara Mannor, Peter W Kaplan, Karl B. Seydel, Yamikani F. Chimalizeni, Kondwani Kawaza, Gretchen L. Birbeck

Research output: Contribution to journalArticle

Abstract

Objectives: Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. Methods: Between 2005 and 2007, survivors of CM and concurrently hospitalized controls in Blantyre, Malawi, were followed to assess the development of neurologic abnormalities. At discharge and every 3 months thereafter, incident cases of epilepsy and developmental disabilities were ascertained using screening questionnaires and confirmatory neurologic examinations. Incident cases of epilepsy and developmental disabilities were compared in retinopathy-negative CM survivors to controls and retinopathy-positive CM survivors. Results: Thirty-five retinopathy-negative CM survivors were enrolled. Their neurologic outcomes were compared to 132 retinopathy-positive CM survivors and 272 controls. Compared to survivors of retinopathy-positive CM, children without malaria retinopathy have an equal odds of adverse neurologic outcome (odds ratio [OR] = 1.0, 95% confidence interval [CI] 0.4-2.2). Eleven of 35 survivors of retinopathy-negative CM had at least 1 adverse neurologic outcome compared to 2 of 272 controls (OR 61.9, 95% CI 13.0-295.5). In retinopathy-negative CM survivors, a Blantyre Coma Scale score

Original languageEnglish (US)
Pages (from-to)1268-1272
Number of pages5
JournalNeurology
Volume79
Issue number12
DOIs
StatePublished - Sep 18 2012

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Cerebral Malaria
Nervous System
Survivors
Developmental Disabilities
Epilepsy
Odds Ratio
Malaria
Confidence Intervals
Nervous System Malformations
Malawi
Neurologic Examination
Coma

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Postels, D. G., Taylor, T. E., Molyneux, M., Mannor, K., Kaplan, P. W., Seydel, K. B., ... Birbeck, G. L. (2012). Neurologic outcomes in retinopathynegative cerebral malaria survivors. Neurology, 79(12), 1268-1272. https://doi.org/10.1212/WNL.0b013e31826aacd4

Neurologic outcomes in retinopathynegative cerebral malaria survivors. / Postels, Douglas G.; Taylor, Terrie E.; Molyneux, Malcolm; Mannor, Kara; Kaplan, Peter W; Seydel, Karl B.; Chimalizeni, Yamikani F.; Kawaza, Kondwani; Birbeck, Gretchen L.

In: Neurology, Vol. 79, No. 12, 18.09.2012, p. 1268-1272.

Research output: Contribution to journalArticle

Postels, DG, Taylor, TE, Molyneux, M, Mannor, K, Kaplan, PW, Seydel, KB, Chimalizeni, YF, Kawaza, K & Birbeck, GL 2012, 'Neurologic outcomes in retinopathynegative cerebral malaria survivors', Neurology, vol. 79, no. 12, pp. 1268-1272. https://doi.org/10.1212/WNL.0b013e31826aacd4
Postels DG, Taylor TE, Molyneux M, Mannor K, Kaplan PW, Seydel KB et al. Neurologic outcomes in retinopathynegative cerebral malaria survivors. Neurology. 2012 Sep 18;79(12):1268-1272. https://doi.org/10.1212/WNL.0b013e31826aacd4
Postels, Douglas G. ; Taylor, Terrie E. ; Molyneux, Malcolm ; Mannor, Kara ; Kaplan, Peter W ; Seydel, Karl B. ; Chimalizeni, Yamikani F. ; Kawaza, Kondwani ; Birbeck, Gretchen L. / Neurologic outcomes in retinopathynegative cerebral malaria survivors. In: Neurology. 2012 ; Vol. 79, No. 12. pp. 1268-1272.
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