Neurologic outcomes in HIV-exposed/uninfected infants exposed to antiretroviral drugs during pregnancy in Latin America and the Caribbean

Alicen B. Spaulding, Qilu Yu, Lucy Civitello, Marisa M. Mussi-Pinhata, Jorge Pinto, Ivete M. Gomes, Jorge O. Alarcón, George K. Siberry, D. Robert Harris, Rohan Hazra

Research output: Contribution to journalArticle

Abstract

To evaluate antiretroviral (ARV) drug exposure and other factors during pregnancy that may increase the risk of neurologic conditions (NCs) in HIV-exposed/uninfected (HEU) infants. A prospective cohort study was conducted at 24 clinical sites in Latin America and the Caribbean. Data on maternal demographics, health, HIV disease status, and ARV use during pregnancy were collected. Infant data included measurement of head circumference after birth and reported medical diagnoses at birth, 6-12 weeks, and 6 months. Only infants with maternal exposure to combination ARV therapy (cART) (≥3 drugs from ≥2 drug classes) during pregnancy were included. Microcephaly, defined as head circumference for age z-score less than -2, and NC were evaluated for their association with covariates, including individual ARVs, using bivariable and logistic regression analyses. From 2002 to 2009, 1,400 HEU infants met study inclusion criteria. At least one NC was reported in 134 (9.6%; 95% confidence interval [CI]: 8.1-11.2), microcephaly in 105 (7.5%; 95% CI: 6.2-9.0), and specific neurologic diagnoses in 33 (2.4%; 95% CI: 1.6-3.3) HEU infants. Microcephaly and NC were not significantly associated with any specific ARV analyzed (p > 0.05). Covariates associated with increased odds of NC included male sex (odds ratio [OR] = 1.9; 95% CI: 1.3-2.8), birth weight

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

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Latin America
Nervous System
HIV
Pregnancy
Microcephaly
Pharmaceutical Preparations
Confidence Intervals
Head
Parturition
Maternal Exposure
Sex Ratio
Birth Weight
HIV-1
Cohort Studies
Logistic Models
Odds Ratio
Regression Analysis
Demography
Prospective Studies
Drug Therapy

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Neurologic outcomes in HIV-exposed/uninfected infants exposed to antiretroviral drugs during pregnancy in Latin America and the Caribbean. / Spaulding, Alicen B.; Yu, Qilu; Civitello, Lucy; Mussi-Pinhata, Marisa M.; Pinto, Jorge; Gomes, Ivete M.; Alarcón, Jorge O.; Siberry, George K.; Harris, D. Robert; Hazra, Rohan.

In: AIDS Research and Human Retroviruses, Vol. 32, No. 4, 01.04.2016, p. 349-356.

Research output: Contribution to journalArticle

Spaulding, AB, Yu, Q, Civitello, L, Mussi-Pinhata, MM, Pinto, J, Gomes, IM, Alarcón, JO, Siberry, GK, Harris, DR & Hazra, R 2016, 'Neurologic outcomes in HIV-exposed/uninfected infants exposed to antiretroviral drugs during pregnancy in Latin America and the Caribbean', AIDS Research and Human Retroviruses, vol. 32, no. 4, pp. 349-356. https://doi.org/10.1089/aid.2015.0254
Spaulding, Alicen B. ; Yu, Qilu ; Civitello, Lucy ; Mussi-Pinhata, Marisa M. ; Pinto, Jorge ; Gomes, Ivete M. ; Alarcón, Jorge O. ; Siberry, George K. ; Harris, D. Robert ; Hazra, Rohan. / Neurologic outcomes in HIV-exposed/uninfected infants exposed to antiretroviral drugs during pregnancy in Latin America and the Caribbean. In: AIDS Research and Human Retroviruses. 2016 ; Vol. 32, No. 4. pp. 349-356.
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