Neurologic manifestations of hepatic disease

Jeffrey D Rothstein, H. F. Herlong

Research output: Contribution to journalArticle

Abstract

Neurologic complications of hepatic disease are not uncommon and involve the CNS more often than the peripheral nervous system or muscles. Progress in the therapy of neurologic disorders associated with hepatic failure has occurred in recent years. Notably, exciting developments in the treatment of hepatic encephalopathy with benzodiazepine antagonists will lead to a better understanding of the pathophysiology of this encephalopathy. The future use of these agents may eventually help reduce the morbidity and mortality of hepatic encephalopathy. The role of this class of drug in other metabolic encephalopathies remains to be established. Furthermore, new therapeutic and surgical alternatives to the treatment of Wilson disease also enhance our therapeutic options. The fate of patients with Wilson disease with fulminant hepatic disease and those patients unable to tolerate or unresponsive to penicillamine therapy has been greatly improved.

Original languageEnglish (US)
Pages (from-to)563-578
Number of pages16
JournalNeurologic Clinics
Volume7
Issue number3
StatePublished - 1989

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Neurologic Manifestations
Liver
Hepatolenticular Degeneration
Hepatic Encephalopathy
Therapeutics
Metabolic Brain Diseases
Penicillamine
Liver Failure
Peripheral Nervous System
Brain Diseases
Nervous System Diseases
Benzodiazepines
Nervous System
Morbidity
Muscles
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neurologic manifestations of hepatic disease. / Rothstein, Jeffrey D; Herlong, H. F.

In: Neurologic Clinics, Vol. 7, No. 3, 1989, p. 563-578.

Research output: Contribution to journalArticle

Rothstein, JD & Herlong, HF 1989, 'Neurologic manifestations of hepatic disease', Neurologic Clinics, vol. 7, no. 3, pp. 563-578.
Rothstein, Jeffrey D ; Herlong, H. F. / Neurologic manifestations of hepatic disease. In: Neurologic Clinics. 1989 ; Vol. 7, No. 3. pp. 563-578.
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