Neurologic complications and considerations in HIV-infected persons

Justin McArthur, Bryan Smith

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Neurologic complications for HIV-infected persons retain significant prevalence despite an increasingly global use of antiretroviral therapies. Such complications are often ascribed to advanced immunosuppression; however, the most common neurologic problems for HIV-infected persons, distal sensory polyneuropathy and HIV-associated neurocognitive disorders, affect a significant proportion of patients who have successfully achieved immunologic restoration with normal or near-normal CD4 count levels and undetectable HIV RNA in the periphery. Understanding specific considerations for HIV-associated complications, including the epidemiology, risk factors, medication-adverse effects, and benefits of appropriate management, is vital for all providers caring for those with HIV. This review will describe such considerations, as well as providing a more detailed review of the most common neurologic complications of HIV infection, and will highlight some of the challenges involved with diagnosis, management, and long-term effects.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalCurrent Infectious Disease Reports
Issue number1
StatePublished - Feb 2013


  • CNS
  • HAND
  • HIV
  • HIV sensory neuropathy
  • HIV-associated neurocognitive disorder
  • Neurologic
  • Review
  • neuroHIV

ASJC Scopus subject areas

  • Infectious Diseases


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