Neurologic aspects of eclampsia

Research output: Contribution to journalReview articlepeer-review


Eclampsia continues to be a significant cause of maternal and fetal death throughout the world. Neurologists have a specific role to play in the diagnosis and management of patients who have eclampsia, especially those who have recurrent seizures, raised intracranial pressure, and coma (Table 10). Postpartum patients may be admitted to a neurology service when they present to the emergency department with seizures. The cornerstone of treatment has been blood pressure control and magnesium sulfate with its antivasospastic effect. Should this fail, antiepileptic drugs of proved efficacy, such as diazepam and phenytoin, can be used. Recent studies reveal genetic and mitochondrial defects in eclampsia, but further investigation is warranted to determine the complex underlying pathophysiologic interplay and the optimum prophylactic and therapeutic management.

Original languageEnglish (US)
Pages (from-to)841-861
Number of pages21
JournalNeurologic clinics
Issue number4 SPEC. ISS.
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Clinical Neurology


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