Neurologic and psychiatric complications of antiretroviral agents

Charles Raines, Olivia Radcliffe, Glenn Jordan Treisman

Research output: Contribution to journalArticle

Abstract

Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.

Original languageEnglish (US)
Pages (from-to)35-48
Number of pages14
JournalJournal of the Association of Nurses in AIDS Care
Volume16
Issue number5
DOIs
StatePublished - Sep 2005

Fingerprint

Anti-Retroviral Agents
Highly Active Antiretroviral Therapy
Nervous System
Psychiatry
Central Nervous System
HIV
Reverse Transcriptase Inhibitors
Drug Combinations
Quality of Life
Pharmaceutical Preparations
Therapeutics

Keywords

  • Antiretroviral
  • HAART
  • HIV
  • Neurologic and psychologic complications

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Neurologic and psychiatric complications of antiretroviral agents. / Raines, Charles; Radcliffe, Olivia; Treisman, Glenn Jordan.

In: Journal of the Association of Nurses in AIDS Care, Vol. 16, No. 5, 09.2005, p. 35-48.

Research output: Contribution to journalArticle

@article{c5e1c54ce43e42b0a9a7ed9db56a3ba7,
title = "Neurologic and psychiatric complications of antiretroviral agents",
abstract = "Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.",
keywords = "Antiretroviral, HAART, HIV, Neurologic and psychologic complications",
author = "Charles Raines and Olivia Radcliffe and Treisman, {Glenn Jordan}",
year = "2005",
month = "9",
doi = "10.1016/j.jana.2005.07.004",
language = "English (US)",
volume = "16",
pages = "35--48",
journal = "Journal of the Association of Nurses in AIDS Care",
issn = "1055-3290",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Neurologic and psychiatric complications of antiretroviral agents

AU - Raines, Charles

AU - Radcliffe, Olivia

AU - Treisman, Glenn Jordan

PY - 2005/9

Y1 - 2005/9

N2 - Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.

AB - Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.

KW - Antiretroviral

KW - HAART

KW - HIV

KW - Neurologic and psychologic complications

UR - http://www.scopus.com/inward/record.url?scp=26944487612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944487612&partnerID=8YFLogxK

U2 - 10.1016/j.jana.2005.07.004

DO - 10.1016/j.jana.2005.07.004

M3 - Article

C2 - 16433108

AN - SCOPUS:26944487612

VL - 16

SP - 35

EP - 48

JO - Journal of the Association of Nurses in AIDS Care

JF - Journal of the Association of Nurses in AIDS Care

SN - 1055-3290

IS - 5

ER -