Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

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Abstract

Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum competes with [3H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalJournal of Nervous and Mental Disease
Volume169
Issue number1
DOIs
StatePublished - Jan 1981

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ASJC Scopus subject areas

  • Psychiatry and Mental health

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