Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

Larry E. Tune; Ian Creese; J. Raymond Depaulo; Phillip R. Slavney; Solomon H. Snyder

doi:10.1097/00005053-198101000-00009

Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

Larry E. Tune, Ian Creese, J. Raymond Depaulo, Phillip R. Slavney, Solomon H. Snyder

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum competes with [³H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	Journal of Nervous and Mental Disease
Volume	169
Issue number	1
DOIs	https://doi.org/10.1097/00005053-198101000-00009
State	Published - Jan 1981

ASJC Scopus subject areas

Psychiatry and Mental health

Access to Document

10.1097/00005053-198101000-00009

Cite this

@article{1d2ae4e5b77e45c1b8b8eff1885c4066,

title = "Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients",

abstract = "Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum competes with [3H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.",

author = "Tune, {Larry E.} and Ian Creese and {Raymond Depaulo}, J. and Slavney, {Phillip R.} and Snyder, {Solomon H.}",

year = "1981",

month = jan,

doi = "10.1097/00005053-198101000-00009",

language = "English (US)",

volume = "169",

pages = "60--63",

journal = "Journal of Nervous and Mental Disease",

issn = "0022-3018",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

AU - Tune, Larry E.

AU - Creese, Ian

AU - Raymond Depaulo, J.

AU - Slavney, Phillip R.

AU - Snyder, Solomon H.

PY - 1981/1

Y1 - 1981/1

N2 - Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum competes with [3H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.

AB - Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum competes with [3H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.

UR - http://www.scopus.com/inward/record.url?scp=0019350186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019350186&partnerID=8YFLogxK

U2 - 10.1097/00005053-198101000-00009

DO - 10.1097/00005053-198101000-00009

M3 - Article

C2 - 6108981

AN - SCOPUS:0019350186

SN - 0022-3018

VL - 169

SP - 60

EP - 63

JO - Journal of Nervous and Mental Disease

JF - Journal of Nervous and Mental Disease

IS - 1

ER -

Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this