TY - JOUR
T1 - Neuroinflammation in amyotrophic lateral sclerosis
T2 - Role of glial activation in motor neuron disease
AU - Philips, Thomas
AU - Robberecht, Wim
N1 - Funding Information:
This work was supported by funding from the Fund for Scientific Research, Flanders ( FWO-V 1.5.081.08 ), University of Leuven ( GOA/11/014 ), Interuniversity Attraction Poles (programme P6/43 of the Belgian Federal Science Policy Office), and Health Seventh Framework Programme ( FP7/2007-2013 ; under grant agreement number 259867 ). TP holds a PhD grant from the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen).
PY - 2011/3
Y1 - 2011/3
N2 - Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of motor neurons. The biological processes that drive this glial reaction are complex and have both beneficial and deleterious effects on motor neurons. Therapeutic interventions targeting these cells are being explored. An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction.
AB - Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of motor neurons. The biological processes that drive this glial reaction are complex and have both beneficial and deleterious effects on motor neurons. Therapeutic interventions targeting these cells are being explored. An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction.
UR - http://www.scopus.com/inward/record.url?scp=79951704433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951704433&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(11)70015-1
DO - 10.1016/S1474-4422(11)70015-1
M3 - Review article
C2 - 21349440
AN - SCOPUS:79951704433
SN - 1474-4422
VL - 10
SP - 253
EP - 263
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 3
ER -