Neuroinflammation in Alzheimer's disease

Michael T. Heneka, Monica J. Carson, Joseph El Khoury, Gary E. Landreth, Frederic Brosseron, Douglas L. Feinstein, Andreas H. Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M. Ransohoff, Karl Herrup, Sally A. Frautschy, Bente Finsen, Guy C. Brown, Alexei Verkhratsky, Koji Yamanaka, Jari Koistinaho, Eicke Latz, Annett Halle, Gabor C. PetzoldTerrence Town, Dave Morgan, Mari L. Shinohara, V. Hugh Perry, Clive Holmes, Nicolas G. Bazan, David J. Brooks, Stéphane Hunot, Bertrand Joseph, Nikolaus Deigendesch, Olga Garaschuk, Erik Boddeke, Charles A. Dinarello, John C.S. Breitner, Greg M. Cole, Douglas T. Golenbock, Markus P. Kummer

Research output: Contribution to journalArticle

Abstract

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)388-405
Number of pages18
JournalThe Lancet Neurology
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

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Alzheimer Disease
Disease Progression
Pattern Recognition Receptors
Brain
Microglia
Innate Immunity
Neuroglia
Astrocytes
Proteins
Obesity
Genome
Inflammation
Genes
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

Cite this

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., ... Kummer, M. P. (2015). Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14(4), 388-405. https://doi.org/10.1016/S1474-4422(15)70016-5

Neuroinflammation in Alzheimer's disease. / Heneka, Michael T.; Carson, Monica J.; Khoury, Joseph El; Landreth, Gary E.; Brosseron, Frederic; Feinstein, Douglas L.; Jacobs, Andreas H.; Wyss-Coray, Tony; Vitorica, Javier; Ransohoff, Richard M.; Herrup, Karl; Frautschy, Sally A.; Finsen, Bente; Brown, Guy C.; Verkhratsky, Alexei; Yamanaka, Koji; Koistinaho, Jari; Latz, Eicke; Halle, Annett; Petzold, Gabor C.; Town, Terrence; Morgan, Dave; Shinohara, Mari L.; Perry, V. Hugh; Holmes, Clive; Bazan, Nicolas G.; Brooks, David J.; Hunot, Stéphane; Joseph, Bertrand; Deigendesch, Nikolaus; Garaschuk, Olga; Boddeke, Erik; Dinarello, Charles A.; Breitner, John C.S.; Cole, Greg M.; Golenbock, Douglas T.; Kummer, Markus P.

In: The Lancet Neurology, Vol. 14, No. 4, 01.04.2015, p. 388-405.

Research output: Contribution to journalArticle

Heneka, MT, Carson, MJ, Khoury, JE, Landreth, GE, Brosseron, F, Feinstein, DL, Jacobs, AH, Wyss-Coray, T, Vitorica, J, Ransohoff, RM, Herrup, K, Frautschy, SA, Finsen, B, Brown, GC, Verkhratsky, A, Yamanaka, K, Koistinaho, J, Latz, E, Halle, A, Petzold, GC, Town, T, Morgan, D, Shinohara, ML, Perry, VH, Holmes, C, Bazan, NG, Brooks, DJ, Hunot, S, Joseph, B, Deigendesch, N, Garaschuk, O, Boddeke, E, Dinarello, CA, Breitner, JCS, Cole, GM, Golenbock, DT & Kummer, MP 2015, 'Neuroinflammation in Alzheimer's disease', The Lancet Neurology, vol. 14, no. 4, pp. 388-405. https://doi.org/10.1016/S1474-4422(15)70016-5
Heneka MT, Carson MJ, Khoury JE, Landreth GE, Brosseron F, Feinstein DL et al. Neuroinflammation in Alzheimer's disease. The Lancet Neurology. 2015 Apr 1;14(4):388-405. https://doi.org/10.1016/S1474-4422(15)70016-5
Heneka, Michael T. ; Carson, Monica J. ; Khoury, Joseph El ; Landreth, Gary E. ; Brosseron, Frederic ; Feinstein, Douglas L. ; Jacobs, Andreas H. ; Wyss-Coray, Tony ; Vitorica, Javier ; Ransohoff, Richard M. ; Herrup, Karl ; Frautschy, Sally A. ; Finsen, Bente ; Brown, Guy C. ; Verkhratsky, Alexei ; Yamanaka, Koji ; Koistinaho, Jari ; Latz, Eicke ; Halle, Annett ; Petzold, Gabor C. ; Town, Terrence ; Morgan, Dave ; Shinohara, Mari L. ; Perry, V. Hugh ; Holmes, Clive ; Bazan, Nicolas G. ; Brooks, David J. ; Hunot, Stéphane ; Joseph, Bertrand ; Deigendesch, Nikolaus ; Garaschuk, Olga ; Boddeke, Erik ; Dinarello, Charles A. ; Breitner, John C.S. ; Cole, Greg M. ; Golenbock, Douglas T. ; Kummer, Markus P. / Neuroinflammation in Alzheimer's disease. In: The Lancet Neurology. 2015 ; Vol. 14, No. 4. pp. 388-405.
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