Neuroimaging of tumefactive multiple sclerosis with atypical features

Rohit Koppula, Andrew J. Degnan, Mark Ghassibi, Peter Duggan, Robert Jones, Lucien M. Levy

Research output: Contribution to journalArticle


Tumefactive demyelinating lesions or tumefactive multiple sclerosis (TMS) constitute a unique presentation of demyelinating disease that frequently mimics intracranial neoplasm, infection or other, nondemyelinating intracranial pathology. Consequently, these lesions, which are larger than typical multiple sclerosis plaques and are generally characterized by certain MRI features including edema and incomplete ring enhancement, pose a serious diagnostic challenge that frequently prompts biopsy in initial evaluation. Biopsy can be averted when imaging features for TMS are seen on MRI. We present a biopsy-proven case of TMS with atypical imaging features, evaluated using MRI and diffusion-tensor imaging.

Original languageEnglish (US)
Article number752
JournalRadiology Case Reports
Issue number4
Publication statusPublished - 2012
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Koppula, R., Degnan, A. J., Ghassibi, M., Duggan, P., Jones, R., & Levy, L. M. (2012). Neuroimaging of tumefactive multiple sclerosis with atypical features. Radiology Case Reports, 7(4), [752].