Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

A. Lerner, A. Bagic, E. A. Boudreau, T. Hanakawa, F. Pagan, Z. Mari, W. Bara-Jimenez, M. Aksu, G. Garraux, J. M. Simmons, S. Sato, D. L. Murphy, M. Hallett

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. METHODS: We used [O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.

Original languageEnglish (US)
Pages (from-to)1979-1987
Number of pages9
JournalNeurology
Volume68
Issue number23
DOIs
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience

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