Neuroimaging of cerebral small vessel disease and age-related cognitive changes

Michelle R. Caunca, Andres De Leon-Benedetti, Lawrence Latour, Richard Leigh, Clinton B. Wright

Research output: Contribution to journalReview articlepeer-review

Abstract

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological cerebrovascular damage in cognitive aging. In this review article, we aim to describe the epidemiology and etiology of various brain magnetic resonance imaging (MRI) measures of vascular damage in cognitively normal, older adult populations. We focus here on population-based prospective cohort studies of cognitively unimpaired older adults, as well as discuss the heterogeneity of MRI findings and their relationships with cognition. This review article emphasizes the need for a better understanding of subclinical cerebrovascular disease in cognitively normal populations, in order to more effectively identify and prevent cognitive decline in our rapidly aging population.

Original languageEnglish (US)
Article number145
JournalFrontiers in Aging Neuroscience
Volume11
Issue numberJUN
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Aging
  • Brain MRI
  • Cerebrovascular disease
  • Cognitive aging
  • Neuroimaging

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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