Neuroimagen y neurotoxicidad inducida por MDMA (éxtasis)

Translated title of the contribution: Neuroimaging MDMA-induced neurotoxicity

Research output: Contribution to journalArticle

Abstract

The increase in the use of ecstasy (MDMA) by young people has let to the study of short and long term effects on the CNS. The existence of serotonergic neurotoxicity has been demonstrated in the last decade. Recent animal studies, including primates, demonstrate and clinical findings suggest dopaminergic damage. Different neuroimaging techniques have contributed to these findings through the study in the different receptor systems involved both presynaptic and postsynaptic levels. The results are obtained from the most relevant studies of neurotoxicity by means of the different neuroimaging techniques (SPECT, PET, MRS, diffusion and perfusion MRI). Considerable evidence from different animal species, including primates, exists that MDMA produces both serotonergic and dopaminergic neurotoxicity. Recent evidence has been published which confirm this findings in humans.

Original languageSpanish
Pages (from-to)111-120
Number of pages10
JournalAdicciones
Volume15
Issue numberSUPPL. 2
StatePublished - 2003

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N-Methyl-3,4-methylenedioxyamphetamine
Neuroimaging
Primates
Diffusion Magnetic Resonance Imaging
Single-Photon Emission-Computed Tomography
Perfusion

Keywords

  • Ecstasy
  • MDMA
  • Neuroimaging
  • Neurotoxicity

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Neuroimagen y neurotoxicidad inducida por MDMA (éxtasis). / McCann, Una D; Ricaurte, George.

In: Adicciones, Vol. 15, No. SUPPL. 2, 2003, p. 111-120.

Research output: Contribution to journalArticle

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