Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions

Theodore J. Passe, Norman J. Beauchamp, Peter C. Burger

Research output: Contribution to journalArticle

Abstract

BACKGROUND- Certain central nervous system (CNS) lesions can be misconstrued histopathologically as high-grade or aggressive neoplasms when they are, in fact, low-grade processes for which surgery alone may be adequate therapy. Reactive lesions such as demyelinating disease can be misinterpreted as well and when diagnosed as a glioma, may be treated with radiotherapy. Complications of treatment, e.g., radionecrosis, are fostered by the long post-therapy survival periods permitted by low-grade neoplasms and, especially, nonneoplastic entities. REVIEW SUMMARY- As a benchmark against which any diagnosis of a CNS tumor should be reconciled is a set of neuroradiological findings that usually indicate a low-grade neoplasm or a reactive nonneoplastic entity. These eight specific radiological features are illustrated in the context of representative low-grade or nonneoplastic CNS lesions. CONCLUSIONS- An interdisciplinary approach, with reconciliation of any discrepancies between neuroimaging features and the pathological diagnosis, can minimize the possibility that patients with suspected CNS tumors will be overtreated.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalNeurologist
Volume5
Issue number6
StatePublished - Nov 1999

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Neuroimaging
Central Nervous System Neoplasms
Central Nervous System
Benchmarking
Neoplasms
Demyelinating Diseases
Glioma
Radiotherapy
Therapeutics
Survival

Keywords

  • Brain
  • CNS
  • Neuroradiology
  • Overtreatment
  • Tumors

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Passe, T. J., Beauchamp, N. J., & Burger, P. C. (1999). Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions. Neurologist, 5(6), 293-299.

Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions. / Passe, Theodore J.; Beauchamp, Norman J.; Burger, Peter C.

In: Neurologist, Vol. 5, No. 6, 11.1999, p. 293-299.

Research output: Contribution to journalArticle

Passe, TJ, Beauchamp, NJ & Burger, PC 1999, 'Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions', Neurologist, vol. 5, no. 6, pp. 293-299.
Passe TJ, Beauchamp NJ, Burger PC. Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions. Neurologist. 1999 Nov;5(6):293-299.
Passe, Theodore J. ; Beauchamp, Norman J. ; Burger, Peter C. / Neuroimaging in the identification of low-grade and nonneoplastic CNS lesions. In: Neurologist. 1999 ; Vol. 5, No. 6. pp. 293-299.
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