Neuroimaging in leukodystrophies

Peter B Barker, Alena Horská

Research output: Contribution to journalArticle

Abstract

The application of techniques based on in vivo magnetic resonance to the study of leukodystrophies is evaluated. Magnetic resonance imaging (MRI), the most important neuroimaging modality for patients with leukodystrophies, has proven invaluable for the detection of the extent and etiology of white-matter involvement, diagnosis, and monitoring of disease progression. Proton magnetic resonance spectroscopy, which can detect several brain metabolites, including those related to axonal function and myelination, can provide additional diagnostic and prognostic information and, in some cases, allows a rare insight into the biochemical pathology of leukodystrophies. The potential of other advanced magnetic resonance techniques, including diffusion tensor imaging, magnetization transfer contrast, and molecular imaging, is also discussed. In the future, anatomic and physiologic magnetic resonance techniques are expected to be integrated into a single examination that will provide a detailed characterization of white-matter diseases in children.

Original languageEnglish (US)
Pages (from-to)559-570
Number of pages12
JournalJournal of Child Neurology
Volume19
Issue number8
StatePublished - Aug 2004

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Neuroimaging
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Leukoencephalopathies
Molecular Imaging
Diffusion Tensor Imaging
Disease Progression
Pathology
Brain
White Matter
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Neuroimaging in leukodystrophies. / Barker, Peter B; Horská, Alena.

In: Journal of Child Neurology, Vol. 19, No. 8, 08.2004, p. 559-570.

Research output: Contribution to journalArticle

Barker, PB & Horská, A 2004, 'Neuroimaging in leukodystrophies', Journal of Child Neurology, vol. 19, no. 8, pp. 559-570.
Barker, Peter B ; Horská, Alena. / Neuroimaging in leukodystrophies. In: Journal of Child Neurology. 2004 ; Vol. 19, No. 8. pp. 559-570.
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