TY - JOUR
T1 - Neuroimaging-genetic paradigms
T2 - A new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia
AU - Roffman, Joshua L.
AU - Weiss, Anthony P.
AU - Goff, Donald C.
AU - Rauch, Scott L.
AU - Weinberger, Daniel R.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Cognitive impairment is a prominent and debilitating feature of schizophrenia. Genetic predisposition likely accounts for a large proportion of these cognitive deficits. Direct associations between candidate genes and cognitive dysfunction have been difficult to establish, however, largely due to the subtle effects of these genes on observable behavior. Neuroimaging techniques can provide a sensitive means to bridge the neurobiology of genes and behavior. Here we illustrate the use of neuroimaging-genetics paradigms to elaborate the relationship between genes and cognitive dysfunction in schizophrenia. After reviewing principles important for the selection of genes, neuroimaging techniques, and subjects, we describe how imaging-genetics investigations have helped clarify the contribution of five candidate genes (COMT, GRM3, G72, DISC1, and BDNF) to cognitive deficits in schizophrenia. The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures.
AB - Cognitive impairment is a prominent and debilitating feature of schizophrenia. Genetic predisposition likely accounts for a large proportion of these cognitive deficits. Direct associations between candidate genes and cognitive dysfunction have been difficult to establish, however, largely due to the subtle effects of these genes on observable behavior. Neuroimaging techniques can provide a sensitive means to bridge the neurobiology of genes and behavior. Here we illustrate the use of neuroimaging-genetics paradigms to elaborate the relationship between genes and cognitive dysfunction in schizophrenia. After reviewing principles important for the selection of genes, neuroimaging techniques, and subjects, we describe how imaging-genetics investigations have helped clarify the contribution of five candidate genes (COMT, GRM3, G72, DISC1, and BDNF) to cognitive deficits in schizophrenia. The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures.
KW - Cognitive impairment
KW - Genetics
KW - Neuroimaging
KW - Schizophrenia
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U2 - 10.1080/10673220600642945
DO - 10.1080/10673220600642945
M3 - Review article
C2 - 16603474
AN - SCOPUS:33645763001
VL - 14
SP - 78
EP - 91
JO - Harvard Review of Psychiatry
JF - Harvard Review of Psychiatry
SN - 1067-3229
IS - 2
ER -