Neurohumoral regulation of the pulmonary circulation during circulatory hypotension in conscious dogs

W. P. Peterson, G. A. Trempy, K. Nishiwaki, Daniel Nyhan, P. A. Murray

Research output: Contribution to journalArticle

Abstract

We investigated the effects of circulatory hypotension (HYPO) on the left pulmonary vascular pressure-flow relationship in chronically instrumented conscious dogs and the role of five neurohumoral mechanisms in either mediating or modulating the response to this stimulus. HYPO was induced by acute (~15-min) inflation of a hydraulic occluder implanted around the thoracic inferior vena cava, which decreased systemic arterial pressure to ~55 mmHg. HYPO resulted in active pulmonary vasoconstriction (53-66%; P <0.01) in intact conscious dogs. Sympathetic α1-adrenoreceptor block reduced (P <0.01) the magnitude of HYPO-induced pulmonary vasoconstriction by 91- 99%. Neither sympathetic β-adrenoreceptor block nor cholinergic muscarinic receptor block had any significant effect on the magnitude of HYPO-induced pulmonary vasoconstriction. Surprisingly, angiotensin II receptor block increased (P <0.05) HYPO-induced pulmonary vasoconstriction by 69-91%. In contrast, arginine vasopressin V1-receptor block reduced (P <0.05) HYPO- induced pulmonary vasoconstriction by 34-41%. These results indicate that the pulmonary circulation of intact conscious dogs is actively regulated by three distinct neurohumoral mechanisms during HYPO. Sympathetic α1- adrenoreceptor activation is the primary mediator of HYPO-induced pulmonary vasoconstriction. Angiotensin II and arginine vasopressin exert opposing pulmonary vasodilator and vasoconstrictor effects during HYPO, whereas sympathetic β-adrenoreceptor and cholinergic muscarinic receptor activation do not appear to modulate the pulmonary vascular response to HYPO.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
JournalJournal of Applied Physiology
Volume75
Issue number4
StatePublished - 1993

Fingerprint

Pulmonary Circulation
Controlled Hypotension
Hypotension
Dogs
Vasoconstriction
Lung
Vasopressin Receptors
Cholinergic Receptors
Muscarinic Receptors
Blood Vessels
Angiotensin Receptors
Arginine Vasopressin
Economic Inflation
Inferior Vena Cava
Vasoconstrictor Agents
Vasodilator Agents
Angiotensin II
Arterial Pressure
Thorax
Pressure

Keywords

  • angiotensin II
  • arginine vasopressin
  • autonomic nervous system
  • cholinergic muscarinic receptors
  • chronic instrumentation
  • hormones
  • pressure-flow plots
  • sympathetic α-adrenoreceptors
  • sympathetic β- adrenoreceptors

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Neurohumoral regulation of the pulmonary circulation during circulatory hypotension in conscious dogs. / Peterson, W. P.; Trempy, G. A.; Nishiwaki, K.; Nyhan, Daniel; Murray, P. A.

In: Journal of Applied Physiology, Vol. 75, No. 4, 1993, p. 1675-1682.

Research output: Contribution to journalArticle

Peterson, WP, Trempy, GA, Nishiwaki, K, Nyhan, D & Murray, PA 1993, 'Neurohumoral regulation of the pulmonary circulation during circulatory hypotension in conscious dogs', Journal of Applied Physiology, vol. 75, no. 4, pp. 1675-1682.
Peterson, W. P. ; Trempy, G. A. ; Nishiwaki, K. ; Nyhan, Daniel ; Murray, P. A. / Neurohumoral regulation of the pulmonary circulation during circulatory hypotension in conscious dogs. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 4. pp. 1675-1682.
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