Neurohumoral mechanism involved in augmentation of canine jejunal absorption following oral rehydration solutions

J. Augusto Bastidas, Michael J. Zinner, Charles J. Yeo

Research output: Contribution to journalArticle

Abstract

Throughout the world diarrheal diseases kill over 5 million children annually. Oral rehydration therapy, initially using glucose-based solutions and more recently cereal-based solutions, prevents complications and death from dehydration. These experiments compared the effect of these two rehydration solutions and a mixed meal on jejunal water and ionic transport. Five dogs had 25-cm proximal jejunal Thiry-Vella fistulae constructed. Following recovery, jejunal absorption studies (N=40) were performed using an isotonic electrolyte solution containing [14C]PEG to calculate net fluxes of water, sodium, and chloride. Each study consisted of a 1-hr basal period, followed by a 3-hr experimental period. Each animal was randomly studied in each of four study groups: control, mixed meal, glucose-based and cereal-based rehydration solution. In the mixed meal, glucose-based, and cereal-based solution groups there were significant increases (P

Original languageEnglish (US)
Pages (from-to)1041-1047
Number of pages7
JournalDigestive Diseases and Sciences
Volume39
Issue number5
DOIs
StatePublished - May 1994

Fingerprint

Rehydration Solutions
Fluid Therapy
Meals
Canidae
Glucose
Isotonic Solutions
Water
Dehydration
Sodium Chloride
Electrolytes
Fistula
Dogs
Control Groups
Edible Grain

Keywords

  • intestinal transport
  • oral rehydration solutions

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Neurohumoral mechanism involved in augmentation of canine jejunal absorption following oral rehydration solutions. / Augusto Bastidas, J.; Zinner, Michael J.; Yeo, Charles J.

In: Digestive Diseases and Sciences, Vol. 39, No. 5, 05.1994, p. 1041-1047.

Research output: Contribution to journalArticle

Augusto Bastidas, J. ; Zinner, Michael J. ; Yeo, Charles J. / Neurohumoral mechanism involved in augmentation of canine jejunal absorption following oral rehydration solutions. In: Digestive Diseases and Sciences. 1994 ; Vol. 39, No. 5. pp. 1041-1047.
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