Neurogenic pulmonary edema in a pulmonary normotensive model

D. L. Beckman, D. D. Ginty, A. C. Gaither

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study our aim was to determine whether or not neurogenic pulmonary edema would develop from a brief pulse of intracranial pressure (ICP) in the absence of any obvious pulmonary hypertension. There were three groups of cats: sham-operated controls, ICP only, and ICP plus variable occlusion of the pulmonary artery. Partial occlusion of the pulmonary artery was carried out by placing a ligature around the pulmonary trunk and mechanically constricting the artery to maintain pulmonary arterial pressure (PAP) and left atrial pressure (LAP) at pre-ICP levels. In sham-operated animals the extravascular lung water/blood free dry weight ratio (EVLW/BFDW) was 3.26±0.07 and broncho-alveolar lavage (BAL) protein, 6.49±0.62 mg/g lung. ICP-only caused a rise in PAP, left atrial pressure, and EVLW/BFDW to 3.67±0.08 (P

Original languageEnglish (US)
Pages (from-to)170-173
Number of pages4
JournalExperimental Biology and Medicine
Volume186
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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