Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases

D. Chichung Lie, Hongjun Song, Sophia A. Colamarino, Guo Li Ming, Fred H. Gage

Research output: Contribution to journalArticlepeer-review

Abstract

New cells are continuously generated from immature proliferating cells throughout adulthood in many organs, thereby contributing to the integrity of the tissue under physiological conditions and to repair following injury. In contrast, repair mechanisms in the adult central nervous system (CNS) have long been thought to be very limited. However, recent findings have clearly demonstrated that in restricted areas of the mammalian brain, new functional neurons are constantly generated from neural stem cells throughout life. Moreover, stem cells with the potential to give rise to new neurons reside in many different regions of the adult CNS. These findings raise the possibility that endogenous neural stem cells can be mobilized to replace dying neurons in neurodegenerative diseases. Indeed, recent reports have provided evidence that, in some injury models, limited neuronal replacement occurs in the CNS. Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)399-421
Number of pages23
JournalAnnual Review of Pharmacology and Toxicology
Volume44
DOIs
StatePublished - 2004

Keywords

  • Adult neural stem cells
  • Cell replacement
  • Recruitment
  • Regeneration
  • Therapy

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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