Neuroendocrine neoplasms of the sinonasal region

Diana Bell, Ehab Y. Hanna, Randal S. Weber, Franco Demonte, Asterios Triantafyllou, James S. Lewis, Antonio Cardesa, Pieter J. Slootweg, Göran Stenman, Douglas R. Gnepp, Kenneth O. Devaney, Juan P. Rodrigo, Alessandra Rinaldo, Bruce M. Wenig, William H. Westra, Justin A. Bishop, Henrik Hellquist, Jennifer L. Hunt, Kimihide Kusafuka, Bayardo Perez-OrdoñezMichelle D. Williams, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalArticle

Abstract

Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - 2015

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Olfactory Esthesioneuroblastoma
Neuroendocrine Carcinoma
Neoplasms
Neuroendocrine Tumors
Electrons
Phenotype

Keywords

  • Immunohistochemistry
  • Neuroendocrine neoplasms
  • Olfactory neuroblastoma
  • Sinonasal carcinoma
  • Sinonasal undifferentiated carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Bell, D., Hanna, E. Y., Weber, R. S., Demonte, F., Triantafyllou, A., Lewis, J. S., ... Ferlito, A. (Accepted/In press). Neuroendocrine neoplasms of the sinonasal region. Head and Neck. https://doi.org/10.1002/hed.24152

Neuroendocrine neoplasms of the sinonasal region. / Bell, Diana; Hanna, Ehab Y.; Weber, Randal S.; Demonte, Franco; Triantafyllou, Asterios; Lewis, James S.; Cardesa, Antonio; Slootweg, Pieter J.; Stenman, Göran; Gnepp, Douglas R.; Devaney, Kenneth O.; Rodrigo, Juan P.; Rinaldo, Alessandra; Wenig, Bruce M.; Westra, William H.; Bishop, Justin A.; Hellquist, Henrik; Hunt, Jennifer L.; Kusafuka, Kimihide; Perez-Ordoñez, Bayardo; Williams, Michelle D.; Takes, Robert P.; Ferlito, Alfio.

In: Head and Neck, 2015.

Research output: Contribution to journalArticle

Bell, D, Hanna, EY, Weber, RS, Demonte, F, Triantafyllou, A, Lewis, JS, Cardesa, A, Slootweg, PJ, Stenman, G, Gnepp, DR, Devaney, KO, Rodrigo, JP, Rinaldo, A, Wenig, BM, Westra, WH, Bishop, JA, Hellquist, H, Hunt, JL, Kusafuka, K, Perez-Ordoñez, B, Williams, MD, Takes, RP & Ferlito, A 2015, 'Neuroendocrine neoplasms of the sinonasal region', Head and Neck. https://doi.org/10.1002/hed.24152
Bell D, Hanna EY, Weber RS, Demonte F, Triantafyllou A, Lewis JS et al. Neuroendocrine neoplasms of the sinonasal region. Head and Neck. 2015. https://doi.org/10.1002/hed.24152
Bell, Diana ; Hanna, Ehab Y. ; Weber, Randal S. ; Demonte, Franco ; Triantafyllou, Asterios ; Lewis, James S. ; Cardesa, Antonio ; Slootweg, Pieter J. ; Stenman, Göran ; Gnepp, Douglas R. ; Devaney, Kenneth O. ; Rodrigo, Juan P. ; Rinaldo, Alessandra ; Wenig, Bruce M. ; Westra, William H. ; Bishop, Justin A. ; Hellquist, Henrik ; Hunt, Jennifer L. ; Kusafuka, Kimihide ; Perez-Ordoñez, Bayardo ; Williams, Michelle D. ; Takes, Robert P. ; Ferlito, Alfio. / Neuroendocrine neoplasms of the sinonasal region. In: Head and Neck. 2015.
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AU - Takes, Robert P.

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