Neuroendocrine liver metastasis treated by using intraarterial therapy: Volumetric functional imaging biomarkers of early tumor response and survival

Vivek Gowdra Halappa, Celia Corona Villalobos, Susanne Bonekamp, Zhen Li, Diane Reyes, David Cosgrove, Timothy M. Pawlik, Luis Alberto Diaz, Nikhil Bhagat, John Eng, Jean François Geschwind, Ihab R Kamel

Research output: Contribution to journalArticle

Abstract

Purpose: To determine if volumetric changes of diffusion-weighted and contrast material-enhanced magnetic resonance (MR) imaging can help assess early tumor response to intraarterial therapy (IAT) in neuroendocrine liver metastasis (NELM). Materials and This retrospective single-center comprehensive imaging Methods: analysis was performed in compliance with HIPAA and was institutional review board approved. Informed patient consent was waived. Seventy-one patients (39 men; mean age, 62.3 years) with NELM treated with IAT were analyzed retrospectively. MR studies were performed before and 3-4 weeks after therapy. The index lesion was segmented to provide volumetric functional analysis of apparent diffusion coefficient (ADC) and contrast-enhanced MR imaging in the hepatic arterial phase (HAP) and portal venous phase (PVP). Tumor response was defined as increase in volumetric ADC of 15% or greater and decrease in volumetric enhancement of 25% or greater during the HAP or of 50% or greater during the PVP. Patient overall survival was the primary end point after therapy initiation. Univariate analysis included Kaplan-Meier survival curves. The Cox proportional hazards regression model was used to detect interactions between volumetric ADC and contrast-enhanced MR imaging and to calculate the hazard ratio. Results: There was significant increase in mean volumetric ADC (27%, P

Original languageEnglish (US)
Pages (from-to)502-513
Number of pages12
JournalRadiology
Volume266
Issue number2
DOIs
StatePublished - Feb 2013

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Tumor Biomarkers
Neoplasm Metastasis
Survival
Liver
Magnetic Resonance Imaging
Health Insurance Portability and Accountability Act
Therapeutics
Research Ethics Committees
Kaplan-Meier Estimate
Informed Consent
Proportional Hazards Models
Contrast Media
Neoplasms
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Neuroendocrine liver metastasis treated by using intraarterial therapy : Volumetric functional imaging biomarkers of early tumor response and survival. / Halappa, Vivek Gowdra; Corona Villalobos, Celia; Bonekamp, Susanne; Li, Zhen; Reyes, Diane; Cosgrove, David; Pawlik, Timothy M.; Diaz, Luis Alberto; Bhagat, Nikhil; Eng, John; Geschwind, Jean François; Kamel, Ihab R.

In: Radiology, Vol. 266, No. 2, 02.2013, p. 502-513.

Research output: Contribution to journalArticle

Halappa, Vivek Gowdra ; Corona Villalobos, Celia ; Bonekamp, Susanne ; Li, Zhen ; Reyes, Diane ; Cosgrove, David ; Pawlik, Timothy M. ; Diaz, Luis Alberto ; Bhagat, Nikhil ; Eng, John ; Geschwind, Jean François ; Kamel, Ihab R. / Neuroendocrine liver metastasis treated by using intraarterial therapy : Volumetric functional imaging biomarkers of early tumor response and survival. In: Radiology. 2013 ; Vol. 266, No. 2. pp. 502-513.
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