Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis

Dennis Drotar, Karen Olness, Max Wiznitzer, Lawrence Marum, Laura Guay, David Hom, Grace Svilar, Chris Schatschneider, Joseph Fagan, Christopher Ndugwa, Rebecca Kiziri Mayengo

Research output: Contribution to journalArticle

Abstract

Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV- 1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV- infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalHealth Psychology
Volume18
Issue number2
DOIs
StatePublished - Mar 1999
Externally publishedYes

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Keywords

  • HIV infection
  • Information-processing ability
  • Mental development
  • Motor development
  • Neurodevelopment
  • Neurologic status

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Drotar, D., Olness, K., Wiznitzer, M., Marum, L., Guay, L., Hom, D., Svilar, G., Schatschneider, C., Fagan, J., Ndugwa, C., & Mayengo, R. K. (1999). Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis. Health Psychology, 18(2), 114-121. https://doi.org/10.1037/0278-6133.18.2.114