Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: Pilot study

G. J. Myers, P. W. Davidson, Christopher Cox, C. F. Shamlaye, M. A. Tanner, O. Choisy, J. Sloane-Reeves, D. O. Marsh, E. Cernichiari, A. Choi, M. Berlin, T. W. Clarkson

Research output: Contribution to journalArticle

Abstract

The Seychelles Child Development Study (SCDS) is testing the hypothesis that prenatal exposure to low concentrations of methylmercury from a maternal diet high in fish is related to the child's developmental outcome. In this report, 217 children from a pilot cohort were reevaluated at 66 months of age. The evaluation included the McCarthy Scales of Children's Abilities, the Preschool Language Scale, and age-appropriate sub-tests from the Woodcock-Johnson Tests of Achievement. Maternal hair total mercury, measured by cold vapor atomic absorption in a maternal hair segment corresponding to pregnancy, revealed a median exposure of 7.1 ppm. The association between maternal hair mercury levels and neurodevelopmental outcomes at 66 months of age was examined by multiple linear regression analysis with adjustment for important confounding variables. The results indicated that mercury exposure was negatively associated with four endpoints (the McCarthy General Cognitive Index and Perceptual Performance subscale and The Preschool Language Scale Total Language and Auditory Comprehension subscale). After normalizing the data by removal of a small number of outliers or highly influential scores, the mercury effects were no longer significant except for auditory comprehension. These results should be viewed as preliminary and interpreted with caution, since the SCDS main study 66-month evaluations, which are better controlled with more detailed endpoints are being analyzed. This study highlights the difficulties in interpreting epidemiologic studies of this type and the degree to which overall results in multivariate analyses can be influenced by a very small number of cases.

Original languageEnglish (US)
Pages (from-to)639-652
Number of pages14
JournalNeuroToxicology
Volume16
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Nutrition
Mercury
Fish
Fishes
Seychelles
Mothers
Hair
Diet
Language
Child Development
Aptitude
Confounding Factors (Epidemiology)
Preschool Children
Linear regression
Regression analysis
Epidemiologic Studies
Linear Models
Multivariate Analysis
Vapors
Regression Analysis

Keywords

  • fetus
  • fish
  • infant
  • methylmercury
  • neurodevelopment
  • newborn
  • Seychelles

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Myers, G. J., Davidson, P. W., Cox, C., Shamlaye, C. F., Tanner, M. A., Choisy, O., ... Clarkson, T. W. (1995). Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: Pilot study. NeuroToxicology, 16(4), 639-652.

Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet : Pilot study. / Myers, G. J.; Davidson, P. W.; Cox, Christopher; Shamlaye, C. F.; Tanner, M. A.; Choisy, O.; Sloane-Reeves, J.; Marsh, D. O.; Cernichiari, E.; Choi, A.; Berlin, M.; Clarkson, T. W.

In: NeuroToxicology, Vol. 16, No. 4, 1995, p. 639-652.

Research output: Contribution to journalArticle

Myers, GJ, Davidson, PW, Cox, C, Shamlaye, CF, Tanner, MA, Choisy, O, Sloane-Reeves, J, Marsh, DO, Cernichiari, E, Choi, A, Berlin, M & Clarkson, TW 1995, 'Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: Pilot study', NeuroToxicology, vol. 16, no. 4, pp. 639-652.
Myers, G. J. ; Davidson, P. W. ; Cox, Christopher ; Shamlaye, C. F. ; Tanner, M. A. ; Choisy, O. ; Sloane-Reeves, J. ; Marsh, D. O. ; Cernichiari, E. ; Choi, A. ; Berlin, M. ; Clarkson, T. W. / Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet : Pilot study. In: NeuroToxicology. 1995 ; Vol. 16, No. 4. pp. 639-652.
@article{d13bc4937ad94d11a4f16fcdd6fc32f6,
title = "Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: Pilot study",
abstract = "The Seychelles Child Development Study (SCDS) is testing the hypothesis that prenatal exposure to low concentrations of methylmercury from a maternal diet high in fish is related to the child's developmental outcome. In this report, 217 children from a pilot cohort were reevaluated at 66 months of age. The evaluation included the McCarthy Scales of Children's Abilities, the Preschool Language Scale, and age-appropriate sub-tests from the Woodcock-Johnson Tests of Achievement. Maternal hair total mercury, measured by cold vapor atomic absorption in a maternal hair segment corresponding to pregnancy, revealed a median exposure of 7.1 ppm. The association between maternal hair mercury levels and neurodevelopmental outcomes at 66 months of age was examined by multiple linear regression analysis with adjustment for important confounding variables. The results indicated that mercury exposure was negatively associated with four endpoints (the McCarthy General Cognitive Index and Perceptual Performance subscale and The Preschool Language Scale Total Language and Auditory Comprehension subscale). After normalizing the data by removal of a small number of outliers or highly influential scores, the mercury effects were no longer significant except for auditory comprehension. These results should be viewed as preliminary and interpreted with caution, since the SCDS main study 66-month evaluations, which are better controlled with more detailed endpoints are being analyzed. This study highlights the difficulties in interpreting epidemiologic studies of this type and the degree to which overall results in multivariate analyses can be influenced by a very small number of cases.",
keywords = "fetus, fish, infant, methylmercury, neurodevelopment, newborn, Seychelles",
author = "Myers, {G. J.} and Davidson, {P. W.} and Christopher Cox and Shamlaye, {C. F.} and Tanner, {M. A.} and O. Choisy and J. Sloane-Reeves and Marsh, {D. O.} and E. Cernichiari and A. Choi and M. Berlin and Clarkson, {T. W.}",
year = "1995",
language = "English (US)",
volume = "16",
pages = "639--652",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet

T2 - Pilot study

AU - Myers, G. J.

AU - Davidson, P. W.

AU - Cox, Christopher

AU - Shamlaye, C. F.

AU - Tanner, M. A.

AU - Choisy, O.

AU - Sloane-Reeves, J.

AU - Marsh, D. O.

AU - Cernichiari, E.

AU - Choi, A.

AU - Berlin, M.

AU - Clarkson, T. W.

PY - 1995

Y1 - 1995

N2 - The Seychelles Child Development Study (SCDS) is testing the hypothesis that prenatal exposure to low concentrations of methylmercury from a maternal diet high in fish is related to the child's developmental outcome. In this report, 217 children from a pilot cohort were reevaluated at 66 months of age. The evaluation included the McCarthy Scales of Children's Abilities, the Preschool Language Scale, and age-appropriate sub-tests from the Woodcock-Johnson Tests of Achievement. Maternal hair total mercury, measured by cold vapor atomic absorption in a maternal hair segment corresponding to pregnancy, revealed a median exposure of 7.1 ppm. The association between maternal hair mercury levels and neurodevelopmental outcomes at 66 months of age was examined by multiple linear regression analysis with adjustment for important confounding variables. The results indicated that mercury exposure was negatively associated with four endpoints (the McCarthy General Cognitive Index and Perceptual Performance subscale and The Preschool Language Scale Total Language and Auditory Comprehension subscale). After normalizing the data by removal of a small number of outliers or highly influential scores, the mercury effects were no longer significant except for auditory comprehension. These results should be viewed as preliminary and interpreted with caution, since the SCDS main study 66-month evaluations, which are better controlled with more detailed endpoints are being analyzed. This study highlights the difficulties in interpreting epidemiologic studies of this type and the degree to which overall results in multivariate analyses can be influenced by a very small number of cases.

AB - The Seychelles Child Development Study (SCDS) is testing the hypothesis that prenatal exposure to low concentrations of methylmercury from a maternal diet high in fish is related to the child's developmental outcome. In this report, 217 children from a pilot cohort were reevaluated at 66 months of age. The evaluation included the McCarthy Scales of Children's Abilities, the Preschool Language Scale, and age-appropriate sub-tests from the Woodcock-Johnson Tests of Achievement. Maternal hair total mercury, measured by cold vapor atomic absorption in a maternal hair segment corresponding to pregnancy, revealed a median exposure of 7.1 ppm. The association between maternal hair mercury levels and neurodevelopmental outcomes at 66 months of age was examined by multiple linear regression analysis with adjustment for important confounding variables. The results indicated that mercury exposure was negatively associated with four endpoints (the McCarthy General Cognitive Index and Perceptual Performance subscale and The Preschool Language Scale Total Language and Auditory Comprehension subscale). After normalizing the data by removal of a small number of outliers or highly influential scores, the mercury effects were no longer significant except for auditory comprehension. These results should be viewed as preliminary and interpreted with caution, since the SCDS main study 66-month evaluations, which are better controlled with more detailed endpoints are being analyzed. This study highlights the difficulties in interpreting epidemiologic studies of this type and the degree to which overall results in multivariate analyses can be influenced by a very small number of cases.

KW - fetus

KW - fish

KW - infant

KW - methylmercury

KW - neurodevelopment

KW - newborn

KW - Seychelles

UR - http://www.scopus.com/inward/record.url?scp=0029589473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029589473&partnerID=8YFLogxK

M3 - Article

C2 - 8714869

AN - SCOPUS:0029589473

VL - 16

SP - 639

EP - 652

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

IS - 4

ER -