Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet

Philip W. Davidson, Donna Palumbo, Gary J. Myers, Christopher Cox, Conrad F. Shamlaye, Jean Sloane-Reeves, Elsa Cernichiari, Gregory E. Wilding, Thomas W. Clarkson

Research output: Contribution to journalArticle

Abstract

The Seychelles Child Development Study has been unable to confirm any relationship between maternal exposure to MeHg during pregnancy and adverse developmental outcomes. In this report, 87 children from a pilot cohort were evaluated at 9 years of age. Each child was given a battery testing specific cognitive, visual motor, and meter skills using standardized psychometric and neuro-psychological tests. The results indicated no adverse association between maternal MeHg exposure and any developmental outcome measure. For three endpoints (Boston Naming Test and two tests of visual motor coordination), enhanced performance in males was associated with increasing prenatal MeHg exposure. A secondary analysis including both prenatal MeHg and postnatal MeHg exposure was done even though we lacked postnatal hair for about 35% of the cohort. The results of the secondary analysis mirrored the outcomes of the primary analysis regarding prenatal exposure but were less robust. The results of this study are consistent with earlier findings from the 66-month evaluations of the SCDS Main cohort. Since MeHg is neurotoxic, this effect is likely due to other factors associated with consumption of fish. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalEnvironmental Research
Volume84
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Maternal Exposure
methylmercury
Nutrition
Fish
Fishes
Seychelles
Mothers
diet
Diet
Psychomotor Performance
Psychological Tests
Motor Skills
fish
Child Development
Psychometrics
Hair
Outcome Assessment (Health Care)
Pregnancy
child development
Testing

Keywords

  • Child development
  • Methylmercury
  • Neuropsychological effects

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet. / Davidson, Philip W.; Palumbo, Donna; Myers, Gary J.; Cox, Christopher; Shamlaye, Conrad F.; Sloane-Reeves, Jean; Cernichiari, Elsa; Wilding, Gregory E.; Clarkson, Thomas W.

In: Environmental Research, Vol. 84, No. 1, 2000, p. 1-11.

Research output: Contribution to journalArticle

Davidson, Philip W. ; Palumbo, Donna ; Myers, Gary J. ; Cox, Christopher ; Shamlaye, Conrad F. ; Sloane-Reeves, Jean ; Cernichiari, Elsa ; Wilding, Gregory E. ; Clarkson, Thomas W. / Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet. In: Environmental Research. 2000 ; Vol. 84, No. 1. pp. 1-11.
@article{0bce4daaa81d4c52883fd5a2b2171b5d,
title = "Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet",
abstract = "The Seychelles Child Development Study has been unable to confirm any relationship between maternal exposure to MeHg during pregnancy and adverse developmental outcomes. In this report, 87 children from a pilot cohort were evaluated at 9 years of age. Each child was given a battery testing specific cognitive, visual motor, and meter skills using standardized psychometric and neuro-psychological tests. The results indicated no adverse association between maternal MeHg exposure and any developmental outcome measure. For three endpoints (Boston Naming Test and two tests of visual motor coordination), enhanced performance in males was associated with increasing prenatal MeHg exposure. A secondary analysis including both prenatal MeHg and postnatal MeHg exposure was done even though we lacked postnatal hair for about 35{\%} of the cohort. The results of the secondary analysis mirrored the outcomes of the primary analysis regarding prenatal exposure but were less robust. The results of this study are consistent with earlier findings from the 66-month evaluations of the SCDS Main cohort. Since MeHg is neurotoxic, this effect is likely due to other factors associated with consumption of fish. (C) 2000 Academic Press.",
keywords = "Child development, Methylmercury, Neuropsychological effects",
author = "Davidson, {Philip W.} and Donna Palumbo and Myers, {Gary J.} and Christopher Cox and Shamlaye, {Conrad F.} and Jean Sloane-Reeves and Elsa Cernichiari and Wilding, {Gregory E.} and Clarkson, {Thomas W.}",
year = "2000",
doi = "10.1006/enrs.2000.4084",
language = "English (US)",
volume = "84",
pages = "1--11",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet

AU - Davidson, Philip W.

AU - Palumbo, Donna

AU - Myers, Gary J.

AU - Cox, Christopher

AU - Shamlaye, Conrad F.

AU - Sloane-Reeves, Jean

AU - Cernichiari, Elsa

AU - Wilding, Gregory E.

AU - Clarkson, Thomas W.

PY - 2000

Y1 - 2000

N2 - The Seychelles Child Development Study has been unable to confirm any relationship between maternal exposure to MeHg during pregnancy and adverse developmental outcomes. In this report, 87 children from a pilot cohort were evaluated at 9 years of age. Each child was given a battery testing specific cognitive, visual motor, and meter skills using standardized psychometric and neuro-psychological tests. The results indicated no adverse association between maternal MeHg exposure and any developmental outcome measure. For three endpoints (Boston Naming Test and two tests of visual motor coordination), enhanced performance in males was associated with increasing prenatal MeHg exposure. A secondary analysis including both prenatal MeHg and postnatal MeHg exposure was done even though we lacked postnatal hair for about 35% of the cohort. The results of the secondary analysis mirrored the outcomes of the primary analysis regarding prenatal exposure but were less robust. The results of this study are consistent with earlier findings from the 66-month evaluations of the SCDS Main cohort. Since MeHg is neurotoxic, this effect is likely due to other factors associated with consumption of fish. (C) 2000 Academic Press.

AB - The Seychelles Child Development Study has been unable to confirm any relationship between maternal exposure to MeHg during pregnancy and adverse developmental outcomes. In this report, 87 children from a pilot cohort were evaluated at 9 years of age. Each child was given a battery testing specific cognitive, visual motor, and meter skills using standardized psychometric and neuro-psychological tests. The results indicated no adverse association between maternal MeHg exposure and any developmental outcome measure. For three endpoints (Boston Naming Test and two tests of visual motor coordination), enhanced performance in males was associated with increasing prenatal MeHg exposure. A secondary analysis including both prenatal MeHg and postnatal MeHg exposure was done even though we lacked postnatal hair for about 35% of the cohort. The results of the secondary analysis mirrored the outcomes of the primary analysis regarding prenatal exposure but were less robust. The results of this study are consistent with earlier findings from the 66-month evaluations of the SCDS Main cohort. Since MeHg is neurotoxic, this effect is likely due to other factors associated with consumption of fish. (C) 2000 Academic Press.

KW - Child development

KW - Methylmercury

KW - Neuropsychological effects

UR - http://www.scopus.com/inward/record.url?scp=0033806985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033806985&partnerID=8YFLogxK

U2 - 10.1006/enrs.2000.4084

DO - 10.1006/enrs.2000.4084

M3 - Article

C2 - 10991777

AN - SCOPUS:0033806985

VL - 84

SP - 1

EP - 11

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

IS - 1

ER -