Neurodevelopmental outcomes in infants requiring resuscitation in developing countries

Waldemar A. Carlo, Shivaprasad S. Goudar, Omrana Pasha, Elwyn Chomba, Elizabeth M. McClure, Fred J. Biasini, Jan L. Wallander, Vanessa Thorsten, Hrishikesh Chakraborty, Linda L. Wright

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment. Study design: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported. Results: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index <85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P =.22) and in other neurodevelopmental outcomes. Conclusions: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments.

Original languageEnglish (US)
Pages (from-to)781-785.e1
JournalJournal of Pediatrics
Volume160
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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