Neurodevelopmental Outcomes in Children Surviving d-Transposition of the Great Arteries

Kathryn A. Ellerbeck, Marla L. Smith, E. Wayne Holden, Susan C. McMenamin, Mohamed A. Badawi, Joel I. Brenner, Jean S. Kan, Susan L. Hyman

Research output: Contribution to journalArticlepeer-review


We investigated the prevalence of neurological abnormalities and learning problems in a population cohort of children with dextro-transposition of the great arteries (d-TGA) born between January 1, 1981 and July 1, 1990. Fifty-seven of the 60 survivors and 35 siblings in the control group underwent neurodevelopmental assessments. As compared with population norms, children with d-TGA were more likely to have abnormal neurological examination findings, learning disabilities, and behavioral disorders. There was no significant difference in IQ or frequency of abnormal neurological examination results between children undergoing atrial as compared with arterial switch procedures. Compared with their siblings, the children with d-TGA had more neurological findings and learning disabilities. The siblings of children with d-TGA had more learning problems than expected. The findings suggest that ongoing surveillance is indicated for children surviving d-TGA. Furthermore, a familial tendency for learning differences should to be taken into consideration when neurodevelopmental outcomes of various perioperative parameters are examined.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalJournal of Developmental and Behavioral Pediatrics
Issue number5
StatePublished - Oct 1998
Externally publishedYes


  • Behavior
  • Neurodevelopmental outcomes
  • Transposition of the great arteries

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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