Neurodevelopmental Origins of Schizophrenia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction What is the evidence that abnormal brain development increases risk? Clues to a molecular mechanism of developmental deviation Why do the clinical manifestations of schizophrenia change over time? Relevant biological events in adolescent brain development Candidate maturational processes and psychosis onset Conclusions References

Original languageEnglish (US)
Title of host publicationSchizophrenia
Subtitle of host publicationThird Edition
PublisherWiley-Blackwell
Pages393-412
Number of pages20
ISBN (Print)9781405176972
DOIs
StatePublished - Mar 8 2011
Externally publishedYes

Keywords

  • Association with maturational deficits and delays in childhood
  • Candidate maturational processes and psychosis onset
  • Epistatic interactions of genes - in NRG1/ERBB4/AKT1 signaling pathway
  • Evidence that abnormal brain development increases risk
  • Genes, objective causative factors - not the only factors
  • Major mysteries about schizophrenia - barely addressed by existing research data
  • Metachromatic leukodystrophy (MLD), rare genetic disorder - of aryl sulfatase deficiency
  • Neurodevelopment hypothesis of schizophrenia - alternative to neurotransmitter hypotheses
  • Neurodevelopmental origins of schizophrenia
  • Three theoretical pillars of neurodevelopmental view of schizophrenia

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Weinberger, D. R., & Levitt, P. (2011). Neurodevelopmental Origins of Schizophrenia. In Schizophrenia: Third Edition (pp. 393-412). Wiley-Blackwell. https://doi.org/10.1002/9781444327298.ch19