Neurodevelopmental hypothesis of schizophrenia

A central sensory disturbance

T. Lafargue, James R Brasic

Research output: Contribution to journalArticle

Abstract

Schizophrenia is a syndrome that is believed to have its onset during very early corticogenesis of the affected patient. The subsequent structural and functional cerebral variations observed in people with schizophrenia suggest an altered overall pattern of brain morphology. The alterations in cerebral structure and function in schizophrenia suggest that an early disturbance of the central nervous sensory modality may be occurring in the patient. Placing the structural and functional cerebral deficits reported in schizophrenia within the context of normal brain structure and function provides a neurological basis to identify early pathological molecular mechanisms and programs that may be resulting in schizophrenia. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalMedical Hypotheses
Volume55
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Schizophrenia
Brain

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Neurodevelopmental hypothesis of schizophrenia : A central sensory disturbance. / Lafargue, T.; Brasic, James R.

In: Medical Hypotheses, Vol. 55, No. 4, 2000, p. 314-318.

Research output: Contribution to journalArticle

@article{b08acfbc2abe442c8f07838db121b526,
title = "Neurodevelopmental hypothesis of schizophrenia: A central sensory disturbance",
abstract = "Schizophrenia is a syndrome that is believed to have its onset during very early corticogenesis of the affected patient. The subsequent structural and functional cerebral variations observed in people with schizophrenia suggest an altered overall pattern of brain morphology. The alterations in cerebral structure and function in schizophrenia suggest that an early disturbance of the central nervous sensory modality may be occurring in the patient. Placing the structural and functional cerebral deficits reported in schizophrenia within the context of normal brain structure and function provides a neurological basis to identify early pathological molecular mechanisms and programs that may be resulting in schizophrenia. (C) 2000 Harcourt Publishers Ltd.",
author = "T. Lafargue and Brasic, {James R}",
year = "2000",
doi = "10.1054/mehy.2000.1059",
language = "English (US)",
volume = "55",
pages = "314--318",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Neurodevelopmental hypothesis of schizophrenia

T2 - A central sensory disturbance

AU - Lafargue, T.

AU - Brasic, James R

PY - 2000

Y1 - 2000

N2 - Schizophrenia is a syndrome that is believed to have its onset during very early corticogenesis of the affected patient. The subsequent structural and functional cerebral variations observed in people with schizophrenia suggest an altered overall pattern of brain morphology. The alterations in cerebral structure and function in schizophrenia suggest that an early disturbance of the central nervous sensory modality may be occurring in the patient. Placing the structural and functional cerebral deficits reported in schizophrenia within the context of normal brain structure and function provides a neurological basis to identify early pathological molecular mechanisms and programs that may be resulting in schizophrenia. (C) 2000 Harcourt Publishers Ltd.

AB - Schizophrenia is a syndrome that is believed to have its onset during very early corticogenesis of the affected patient. The subsequent structural and functional cerebral variations observed in people with schizophrenia suggest an altered overall pattern of brain morphology. The alterations in cerebral structure and function in schizophrenia suggest that an early disturbance of the central nervous sensory modality may be occurring in the patient. Placing the structural and functional cerebral deficits reported in schizophrenia within the context of normal brain structure and function provides a neurological basis to identify early pathological molecular mechanisms and programs that may be resulting in schizophrenia. (C) 2000 Harcourt Publishers Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0033783540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033783540&partnerID=8YFLogxK

U2 - 10.1054/mehy.2000.1059

DO - 10.1054/mehy.2000.1059

M3 - Article

VL - 55

SP - 314

EP - 318

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 4

ER -