Neurodegeneration: Nicked to Death

David M. Wilson, Mark P Mattson

Research output: Contribution to journalArticle


Ataxia oculomotor apraxia-1 is a neurological disorder that arises from mutations in the gene encoding the protein aprataxin. A recent study demonstrates that aprataxin is critical for the processing of obstructive DNA termini, suggesting a broader role for DNA single-strand break repair in neurodegenerative disease.

Original languageEnglish (US)
JournalCurrent Biology
Issue number2
StatePublished - Jan 23 2007
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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